We study dental biofilm composition, architecture and metabolic activity, with particular focus on the biofilm matrix and its role in dental disease. We work on 3-dimensional analysis of biofilm pH and develop novel approaches for biofilm control that preserve the benefits of the commensal microbiota.
Through an interdisciplinary research network, we work with bone tissue engineering and surface functionalization for enhancement of osseointegration of dental implants using cell culture and animal studies. The research is mainly embedded in the department core facility: The Research Laboratories.
Our research focuses on microbiological and structural aspects of natural dental biofilm to understand ecological interactions among microorganisms in relation to biofilm and caries formation. We use novel techniques to describe 3-D microbial communities and pH landscapes within intact in situ and in vivo dental biofilms.
We study antimicrobial resistance focusing on the methodology of antimicrobial susceptibility testing, resistance mechanisms in oral bacteria, and antimicrobial resistance in the Danish population. We also seek to elucidate the importance of the periodontal pathogen Aggregatibacter actinomycetemcomitans in human disease.
We seek to optimize the use of fluoride for caries control, and explore the dynamics of fluoride at various concentrations in the different oral cavity compartments (dental biofilm, saliva and oral mucosa). Our laboratory masters a fluoride microanalysis set-up, available only in few places in the world.
Our research is dedicated to examining the use of dental services within the general population and special groups, such as prisoners. By analyzing health registers, we also explore the correlation between systemic diseases and dental service use. Overarching goal is to gather insights that inform the allocation of dental services in Denmark and other Nordic countries.
Our research focuses on biofilm metabolism, with a particular focus on extracellular pH modulating factors as a means to increase our knowledge on dental caries. We develop novel laboratory techniques to study dental biofilms at the microscale, including additively manufactured flow models that closely mimic the oral environment.