Publications - Publikationer en-us PURE Extension (Web Department) 30 <![CDATA[The Effect of Ligature Type on Lateral Tooth Movement during Orthodontic Treatment with Lingual Appliances—An In Vitro Study]]> Reichardt, E., Decker, S., Dalstra, M., et al. (1) Background: One of the most challenging parts in lingual orthodontics is the control and correction of the tip of anterior teeth, due to the occlusal open vertical slot of the incisors in lingual systems. The presented experimental in-vitro study was performed to determine the maximal tipping moment of the anterior teeth between two types of lingual brackets, the Incognito™ Appliance System (Incognito, TOP-Service, Bad Essen, Germany) and Tip-Bar™ system (Incognito, TOP-Service, Bad Essen, Germany). Furthermore, twelve different ligation methods and two different ligature materials were investigated. (2) Methods: The measurement was performed by assessing the stiffness and ultimate strength of the ligature in a uniaxial material testing machine (Instron, Norwood, MA, USA) using a 0.025 × 0.018 inch stainless steel wire. (3) The results showed that the highest precision for control tipping of anterior teeth was determined for the 0.010 inch Stainless Steel Tie (Pelz and Partner). Furthermore, the Tip-Bar™ brackets increased the maximal moment by 33.8% for elastic and steel ligatures. (4) Conclusions: The lateral tooth movement is highly dependent on the type of ligature and applied material during orthodontic treatment with lingual appliances. The use of 0.010 inch steel ligatures and the Tip-Bar™ bracket design results in better alignment in the anterior teeth segment.

Forskning Sun, 01 May 2022 21:35:15 +0200 13f44534-b682-453f-9ddd-6e3247a3ace9
<![CDATA[The Highly Leukotoxic JP2 Genotype of <i>Aggregatibacter actinomycetemcomitans</i> Is Present in the Population of the West African Island, Sal in Cape Verde]]> De Soet, J. J., Claesson, R., Haubek, D., Johansson, A., Buijs, M. J., Volgenant, C. M.C. Aggregatibacter actinomycetemcomitans is strongly associated with severe periodontitis, possibly due to its production of a potent leukotoxin. A genetic variant, the JP2 genotype, was found to produce more leukotoxin than the wild type because of a mutation in the leukotoxin gene, and this genotype is frequently found in African populations. The aim of this study was to investigate whether this JP2 genotype can be found in a randomly selected group of inhabitants of Sal, Cape Verde. Twenty-nine adults between 20 and 59 years of age (58.6% female) participated, and information on their oral health and living standards was collected. An oral examination was performed for each participant, including DMF-T and CPI scores. Plaque and saliva samples were collected and transported to Europe, where DNA was isolated, and the concentration of A. actinomycetemcomitans and its JP2 genotype was determined using dedicated PCR analyses. All 29 plaque and 31% of the saliva samples harboured A. actinomycetemcomitans, and two participants were positive for the JP2 genotype. The presence of this JP2 genotype was not associated with either CPI or DMF-T. This pilot study is the first to describe the presence of the A. actinomycetemcomitans JP2 genotype in a Cape Verdean population living in the Cape Verde Islands, and the findings warrant further research.

Forskning Sun, 01 May 2022 21:35:15 +0200 1212f2bc-2028-48c3-b55c-fe3f1aa6d146
<![CDATA[Behandling af trangstilling]]> Laursen, M. G., Botticelli, S. til, at patienten er utilfreds med sit smil. Overordnet er der tre strategier for behandling af pladsmangel: 1) ekspansion, 2) interproksimal reduktion og
3) ekstraktion. Det er ikke alene trangstillingens sværhedsgrad, der afgør behandlingsstrategien, idet interventionen sigter mod harmonisk facial
æstetik, normal orofacial funktion og parodontal sundhed. Klinikeren baserer den individualiserede behandlingsplan på det fulde ortodontiske registreringsmateriale. Pladsforholdene vurderes specielt i relation til tændernes bukkolingvale inklination, ansigtets fysiognomi, okklusionen, læbe- og tungefunktionen og parodontiets biotype. Ekspansion, ekstraktion eller interproksimal reduktion er komplementære strategier og kan kombineres i forhold til individuelle problemstillinger. Diverse faste og aftagelige typer af apparatur besidder forskellige egenskaber. Apparaturdesign selekteres under
hensyntagen til behandlingsmålet og de planlagte tandbevægelser.]]>
Formidling Mon, 01 Aug 2022 21:35:15 +0200 22f96a6b-f360-4719-a52b-19d0d60a4e66
<![CDATA[Editorial]]> Salmi, M., Wolff, J., Mäkitie, A. Forskning Sat, 01 Jan 2022 21:35:15 +0100 73374d68-9856-4f60-8754-a67600280109 <![CDATA[Effect of osseodensification on the increase in ridge thickness and the prevention of buccal peri-implant defects]]> Frizzera, F., Spin-Neto, R., Padilha, V., et al. Background: Implant installation with conventional drilling can create buccal bone defects in areas of limited ridge thickness. Implant installation with osseodensification may aid in preventing buccal bone defects in these situations. This in vitro pilot study evaluated the impact of osseodensification on the increase in alveolar ridge thickness and the prevention of buccal peri-implant defects. Methods: Ten fresh pig mandibles with limited bone thickness were selected for use in an experimental randomized split mouth pilot study. Two site-preparation protocols were used: conventional drilling with cutting burs (CTL, n = 10) and osseodensification with Densah® burs (OD, n = 10). After implant bed preparation, 20 implants (4.5 × 10 mm) were placed in the prepared sites and the insertion torque was recorded. Clinical and photographic analysis evaluated ridge thickness and the extent (height, width, and area) of bone defects in the buccal and lingual bone walls following implant placement. Three-dimensional measurements were performed using STL files to analyze the increase in buccal ridge thickness following site preparation and implant placement. The height of the buccal bone defect was considered as the primary outcome of this study. Defect width, area, implant insertion torque, and linear buccal ridge increase after implant site preparation and installation were also assessed. Non-parametric evaluations were carried out with the Mann–Whitney test to verify intergroup differences. Results: There was no statistically significant difference between groups in the baseline ridge thickness. OD presented a significantly higher insertion torque, associated with reduced buccal and lingual bone defect width, in comparison to CTL. Conclusions: The increase in buccal ridge thickness after site preparation and implant placement was significantly higher in OD compared to CTL. Osseodensification increased the ridge thickness through expansion and reduced buccal bone defects after implant installation.

Forskning Sat, 01 Jan 2022 21:35:15 +0100 d77538df-bacc-4513-8a86-8338af33e04f
<![CDATA[Clinical identification of the stimulus intensity to measure temporal summation of second pain]]> Moriguchi, D., Ishigaki, S., Lin, X., et al. Temporal summation of second pain (TSSP) has been suggested as a psychophysical index for central sensitization, one of the critical mechanisms in the chronification of pain. However, there is no gold standard for protocols to measure TSSP. The purpose was to establish the stimulus intensity for measuring TSSP. Female patients with chronic myofascial temporomandibular disorders pain (n = 16) and healthy female volunteers with no pain (n = 15) participated. Pain thresholds (PT °C) were measured, and repetitive heat stimuli at three stimulus intensities (PT °C, PT + 1 °C, PT + 2 °C) were applied. TSSP parameters were quantified as TSSP magnitude (TSm) and TSSP frequency (TSf). In healthy female volunteers, pain ratings significantly decreased at PT °C (p < 0.050), besides TSm and TSf at PT + 2 °C were significantly higher than those at PT °C (p < 0.025). In chronic pain patients, pain ratings significantly increased at PT + 1 °C and PT + 2 °C (p < 0.050). At PT + 2 °C, TSm and TSf in chronic pain patients were significantly higher than those in healthy volunteers (p < 0.050). It could be helpful to measure TSSP with the stimulus intensity adjusted individually to the patient’s pain thresholds + 2 °C for assessing central sensitization.

Forskning Thu, 28 Jul 2022 21:35:15 +0200 03a18126-8ec4-4e72-8945-6b7c1c7440df
<![CDATA[Application of platelet-rich fibrin after surgical extraction of the mandibular third molar]]> Snopek, Z., Hartlev, J., Væth, M., Nørholt, S. E. Aim: To evaluate existing double-blinded randomised clinical trials (RCTs) and to clarify if platelet-rich fibrin (PRF) has beneficial effects to reduce postoperative complications after mandibular third molar surgery. Materials and Methods: An electronic search was performed of the PubMed/MEDLINE, Embase, Cochrane Library, Scopus and Web of Science databases to identify clinical studies. In addition, relevant journals, trials in the grey literature and reference lists of identified publications were screened for additional studies. Quality assessment of included trials was performed using eight quality criteria and the Cochrane Collaboration tool for determination of the risk of bias. Studies with a good or moderate quality were included in a descriptive synthesis and meta-analysis. Results: After identification of 221 publications, 215 trials were excluded. The remaining six studies indicated an advantageous effect of PRF in reducing the frequency of alveolar osteitis (AO) and an unclear effect of PRF on postoperative pain levels, oedema and wound healing after mandibular third molar surgery. A meta-analysis comparing results on pain levels did not show a significant effect of PRF. Conclusions: Due to a small number of included studies, it was not possible to evaluate the effect of PRF after mandibular third molar surgery. Future trials should focus on a higher methodological quality to produce reliable and comparable study results.

Forskning Mon, 01 Aug 2022 21:35:15 +0200 2ae9dd34-24ff-4ebc-8cec-616ec8d1e4cc
<![CDATA[Establishing a Core Outcome Set for Endodontic Treatment modalities]]> El Karim, I., Duncan, H. F., Cushley, S., et al. Forskning Fri, 01 Jul 2022 21:35:15 +0200 04a95349-d6bc-45c1-86c6-eaa059fbbea3 <![CDATA[Studies in patients with temporomandibular disorders pain]]> Abrahamsen, R., Naish, P. Many medical conditions are claimed to benefit when hypnosis is incorporated into their treatment. For some conditions, the claims are largely anecdotal, but the treatment of pain stands out in two ways. First, there is a strong body of evidence that hypnosis can produce clinically useful analgesic effects. Second, since innocuous pain can be induced in the laboratory, the process can be explored rigorously. This idea assumes that experimentally induced pain and clinical pain behave identically. We describe using experimentally induced pain in patients already suffering from temporomandibular disorders. Scanning results indicate that the pain and its amelioration are the same in the two circumstances. Moreover, the absence of any impact upon a nociceptive trigemino-facial reflex implies that the impact of hypnosis is purely cortical. Finally, we address the observation that clinical success correlates poorly with hypnotic susceptibility scores. It is proposed that a painful experimental situation induces anxiety. This, like hypnosis, has been associated with an emphasis on right hemisphere activity. Thus, clinical anxiety may render a person more responsive to hypnosis than would be indicated by a susceptibility test delivered in stress-free circumstances.

Forskning Sat, 01 Oct 2022 21:35:15 +0200 93ca6f24-581f-49b2-9cee-2016e57832dc
<![CDATA[Translation and cross-cultural adaptation of the sleep-related breathing disorder scale of the Pediatric Sleep Questionnaire into Danish language]]> Niu, X., Yung, A. K.C., Strickertsson, T. I. B., Stoustrup, P., Cornelis, M. A., Cattaneo, P. M. Objective/Background: Sleep-disordered breathing (SDB) is common but often underestimated in children. The gold standard for assessing SDB is polysomnography, but it is expensive and time-consuming. The Paediatric Sleep Questionnaire (PSQ/SRDB) is a validated screening tool for SDB, which represents an efficient and alternative tool for screening SDB among children. However, a translated and validated Danish version of the PSQ/SRDB is not available yet. Our aim was to cross-culturally translate the PSQ/SRDB into Danish language for use in clinical and research settings. Patients/Methods: The translation was carried out through forward-backward translation techniques performed by a panel of experts, and the cross-cultural adaptation was achieved by pretesting of the pre-final version. Internal consistency of the Danish PSQ/SRDB version was measured by Cronbach's alpha coefficients, while Cohen’s kappa was used to evaluate test-retest reliability. Construct validity was assessed by factor analysis of the principal components. Results: The Danish PSQ/SRDB was administered to the caregivers of 348 children. An overall Cronbach’s alpha of 0.72 was found, confirming the survey’s consistency, with the results for the domains ranging 0.52–0.70. The Danish PSQ/SRDB showed moderate to perfect reliability for all items, except for one question (C14). Factor analysis performed on the Danish PSQ/SRDB showed that the predetermined four factors were similar with the original version of the PSQ/SRDB. Conclusions: The Danish version of the PSQ/SRDB has been successfully translated and cross-culturally adapted, suggesting that it can be used as an appropriate paediatric screening tool for SDB in Denmark.

Forskning Mon, 01 Aug 2022 21:35:15 +0200 fa89b843-03dc-4943-abcc-0f7600117816
<![CDATA[Salivary changes in chronic kidney disease and in patients undergoing hemodialysis]]> Rodrigues, R. P. C. B., Vidigal, M. T. C., Vieira, W. A., et al. Objectives: This study is aimed at describing changes in salivary flow rate and ionic composition present in the saliva of chronic kidney disease (CKD) patients by assessing the pH, calcium, phosphate, and phosphorus concentrations and comparing them to healthy individuals, along with exploring the influence of hemodialysis on these parameters. Methods: The bibliographical search was performed in nine databases to find all types of studies, including observational clinical studies, without restrictions regarding publication year or language. Two reviewers selected the studies, extracted the data, and assessed the risk of bias using JBI tools. Random-effect meta-analysis was performed with the standardized mean difference (SMD) as effect estimate, at a 95% confidence interval. Results: Thirty-three studies were included in the qualitative synthesis and 31 studies were included in the meta-analysis. Chronic kidney disease patients presented lower salivary flow rate (SMD: − 1.73; 95% CI = − 2.14; − 1.31), higher pH (SMD: 1.57; 95% CI = 1.11; 2.03), and higher phosphorus concentration (SMD: 0.86; 95% CI = 0.63; 1.09) in saliva. Concurrently, salivary flow rate and pH presented significant changes after hemodialysis, with higher salivary flow rate (SMD: 0.53; 95% CI = 0.25; 0.81) and lower pH (SMD: − 0.53; 95% CI = − 0.88; − 0.19) in patients on hemodialysis treatment. Conclusion: Chronic kidney disease patients present reduced salivary flow rate and increased pH and phosphorus concentration in saliva. Hemodialysis can increase the salivary flow rate of these patients.

Forskning Wed, 01 Jun 2022 21:35:15 +0200 57689de8-202a-4491-a4cb-8f752e9129c3
<![CDATA[Assessment of masticatory efficiency based on glucose concentration in orthodontic patients - a methodological study]]> Aiyar, A., Shimada, A., Svensson, P. INTRODUCTION: Treatment for malocclusion can cause discomfort and pain in the teeth and periodontium, which may impair masticatory efficiency. The glucose concentration method is widely used to assess masticatory efficiency for its convenience in the clinical situation, although its validity has not been shown.

OBJECTIVE: The aims were to determine the validity of the glucose concentration method and investigate if this method can be applicable to orthodontic patients with braces.

DESIGN: Sixteen healthy individuals (7 men, 9 women, and 26±5 years old) and 16 patients with malocclusions needing orthodontic treatment (5 men, 11 women, and 26±4 years old) participated. Glucose concentration was measured after 5-, 10-, and 15-s mastication of gummy jelly and compared to Hue values obtained from the color-changing gum method (reference method). In addition, all participants were asked to fill out the Oral Health Impact Profile questionnaire (OHIP) to assess differences in perception related to the mouth before and after the placement of braces.

RESULTS: Glucose concentrations were strongly correlated to measures of the two-color chewing gum methods (R2 =0.965). Both the glucose extraction and chewing gum hue value were the smallest for 5 s chewing cycles and increased as the number of chewing strokes increased for the 15 s chewing cycles. (Hue: R2 = 0.510, P < 0.001; glucose: R2 = 0.711, P < 0.001) Masticatory efficiency assessed by both methods was significantly lower in orthodontic patients compared to controls (P<0.05), even though it was not affected by bonding (P>0.09). In addition, OHIP scores in physical pain dimension and psychological disability were higher in orthodontic patients than in the control group (P<0.005).

CONCLUSION: Measurement of glucose concentration was confirmed as a reliable and convenient method for assessing masticatory efficiency. Furthermore, it appears that this method is applicable to patients with braces whose perception in the oral cavity could change.

Forskning Sat, 01 Oct 2022 21:35:15 +0200 1da15007-4e29-4173-84ae-87f511f1f8e0
<![CDATA[Features and methods to discriminate between mechanism-based categories of pain experienced in the musculoskeletal system]]> Shraim, M. A., Sluka, K. A., Sterling, M., et al. ABSTRACT: Classification of musculoskeletal pain based on underlying pain mechanisms (nociceptive, neuropathic, and nociplastic pain) is challenging. In the absence of a gold standard, verification of features that could aid in discrimination between these mechanisms in clinical practice and research depends on expert consensus. This Delphi expert consensus study aimed to: (1) identify features and assessment findings that are unique to a pain mechanism category or shared between no more than 2 categories and (2) develop a ranked list of candidate features that could potentially discriminate between pain mechanisms. A group of international experts were recruited based on their expertise in the field of pain. The Delphi process involved 2 rounds: round 1 assessed expert opinion on features that are unique to a pain mechanism category or shared between 2 (based on a 40% agreement threshold); and round 2 reviewed features that failed to reach consensus, evaluated additional features, and considered wording changes. Forty-nine international experts representing a wide range of disciplines participated. Consensus was reached for 196 of 292 features presented to the panel (clinical examination-134 features, quantitative sensory testing-34, imaging and diagnostic testing-14, and pain-type questionnaires-14). From the 196 features, consensus was reached for 76 features as unique to nociceptive (17), neuropathic (37), or nociplastic (22) pain mechanisms and 120 features as shared between pairs of pain mechanism categories (78 for neuropathic and nociplastic pain). This consensus study generated a list of potential candidate features that are likely to aid in discrimination between types of musculoskeletal pain.

Forskning Thu, 01 Sep 2022 21:35:15 +0200 93963e00-902d-4d8f-856e-15c551a8cb9d
<![CDATA[Systemic administration of monosodium glutamate induces sexually dimorphic headache- and nausea-like behaviours in rats]]> Benbow, T., Ekbatan, M. R., Wang, G. H. Y., et al. ABSTRACT: Ingestion of monosodium glutamate (MSG) causes headache, nausea, and craniofacial tenderness in healthy individuals. The present study explored whether MSG produces behavioural signs of headache, nausea, and changes in craniofacial sensitivity in rats. The behavior of male and female Sprague-Dawley rats was video recorded before and after intraperitoneal (i.p.) injections of MSG (1-1000 mg/kg), nitroglycerin (GTN, 10 mg/kg), or normal saline. Behaviors (grimace score, head-flicks, rearing, head scratches, facial grooming, lying-on-belly, and temporalis muscle region mechanical withdrawal threshold) were evaluated. Facial cutaneous temperature of the nose and forehead was measured before and after i.p. injections via infrared thermography. Plasma glutamate and calcitonin gene-related peptide concentrations after administration of 1000 mg/kg MSG were measured in anesthetized rats. Monosodium glutamate induced nocifensive, headache-like, and nausea-like behaviors in a dose-related manner but had no effect on mechanical threshold. Monosodium glutamate (1000 mg/kg) induced a significantly greater frequency of headache-like behavior in females but a longer duration of nausea-like behavior in males. Monosodium glutamate produced a prolonged increase in plasma glutamate and calcitonin gene-related peptide concentrations. Co-administration of the median effective dose of MSG (350 mg/kg) with GTN (10 mg/kg) amplified headache-like behaviors, induced significant craniofacial sensitivity, and produced increased nausea-like behaviour. Co-administration of sumatriptan or naproxen with MSG (1000 mg/kg) significantly attenuated MSG-induced nocifensive and headache-like behaviors. Our data suggest that systemic administration of MSG to rats induces behavioral correlates of headache and nausea. This model may offer another avenue for research on the mechanism and treatment of primary headache disorders such as migraine.

Forskning Thu, 01 Sep 2022 21:35:15 +0200 12c096a8-5881-48cb-9fd2-c89c96c8faf0
<![CDATA[Antimicrobial and mechanical properties of orthodontic acrylic resin containing zinc oxide and titanium dioxide nanoparticles supported on 4A zeolite.]]> Esmaeilzadeh, M. ., Divband, . B. ., Ranjkesh, B., Pournaghi Azar, F., Yeganeh Sefidan, . F. ., Kachoei, . M. . Forskning Fri, 01 Jul 2022 21:35:15 +0200 4b73cbbc-c27d-4a84-ad8c-5b7d84072281 <![CDATA[Vitamin D status and tooth enamel hypomineralization are not associated in 4-y-old children]]> Mortensen, N. B., Haubek, D., Dalgård, C., et al. Early fetal stages of tooth development are vitamin D-dependent, suggesting an impact of vitamin D status in pregnancy on tooth mineralization in human populations. We examined the association between pregnancy and cord serum 25-hydroxyvitamin D (s-25(OH)D) and hypomineralization of the second primary molars (HSPM) in the 4-year-old children in the prospective, population-based Odense Child Cohort, Denmark. S-25(OH)D was measured in early pregnancy (<20 weeks, n = 753); late pregnancy (≥20 weeks, n = 841); and in umbilical cord blood (n = 1,241) using liquid chromatography-tandem mass spectrometry. HSPM was scored using modified European Academy of Paediatric Dentistry judgment criteria. The median [Q1;Q3] s-25(OH)D was 65.0 [49.4;78.0], 79.2 [60.4;95.8], and 45.1 [31.2;60.5] nmol/L in early pregnancy, late pregnancy, and cord blood, respectively. The prevalence of HSPM was 54.7%; creamy/white demarcated opacities 79.5%; yellowish/brownish demarcated opacities 14.9%; post-eruptive breakdown 5.2%; atypical restoration 0.4%. No univariate or adjusted associations with HSPM were detected for pregnancy or cord s-25(OH)D as a continuous variable or categorized into quartiles or routine clinical cut-offs, or when classifying HSPM by severity. In exploratory multiple regression analysis, HSPM was inversely associated with the length of gestation, adjusted odds ratio (aOR) 0.82 (95% C.I 0.74–0.92, p < 0.001), and directly associated with maternal education, aOR 1.57 (95% C.I 1.18–2.08, p = 0.002). In a population with relatively high s-25(OH)D concentrations and generally healthy mothers and children, pregnancy and cord blood vitamin D status was not associated with HSPM. The associations between HSPM and shorter gestational length and higher maternal education warrant further study.

Forskning Fri, 01 Jul 2022 21:35:15 +0200 3cbd712e-4706-48e0-aa12-91fb97f8a0fb
<![CDATA[Impact of oral motor task training on corticomotor pathways and diadochokinetic rates in young healthy participants]]> Boscato, N., Hayakawa, H., Iida, T., et al. Forskning Thu, 01 Sep 2022 21:35:15 +0200 0939fff8-bb9a-4d84-95cb-81b08fc799b8 <![CDATA[Minimizing patient morbidity after free gingival graft harvesting:A triple-blind randomized-controlled clinical trial]]> Bitencourt, F. V., Cardoso De David, S., Schutz, J. d. S., Otto Kirst Neto, A., Visioli, F., Fiorini, T. Objectives: This study aimed to evaluate the effect of photobiomodulation therapy (PBMT) on patient morbidity and donor site healing after free gingival graft (FGG) harvesting. Methods: Forty-four patients requiring FGG were selected for this trial. Individuals were randomly assigned to test group (PBMT, n = 22) or control group (placebo, n = 22) applied immediately after surgery, 24 and 48 h after. Demographic, surgical-related and psychosocial variables possibly associated with treatment response were collected. The primary outcome was postoperative pain at the donor site evaluated using Visual Analog Scale (VAS) immediately after surgery and 6, 24, 48 and 72 h after. Secondary outcomes include medication consumption, patient-reported outcome measures (PROMs) and percentage of wound closure. Results: Intragroup analysis showed no differences in VASLOG means for placebo group throughout the study (p >.05), whereas a significant difference in PBMT group at 6 h, 24 h, 48 h and 72 h (p <.05) were observed. Postoperative rescue analgesic requirement was significantly higher in the placebo group (p =.004). The number needed to treat(NNT) was 2.43. PBMT group reported significant better function related to sleeping, going to work/school and daily routine activities, less restriction to mouth opening, chewing and food consumption, less swelling and bleeding (p <.05), mainly in the first 48 h. PBMT group presented a significantly higher palatal wound closure at 7 days compared to placebo group (33.41 vs. 21.20 respectively, p =.024) after adjustment for confounding. No adverse effects were reported. Conclusions: Photobiomodulation therapy accelerated the pain resolution time and palatal closure, decreased rescue medication consumption and significantly improved patient satisfaction in the postoperative period.

Forskning Wed, 01 Jun 2022 21:35:15 +0200 021966e8-d766-4031-b354-40eaf7207289
<![CDATA[Investigating oral and systemic pathways between unhealthy and healthy dietary patterns to periodontitis in adolescents]]> Costa, S. A., Nascimento, G. G., Colins, P. M. G., et al. Aim: To investigate pathways between unhealthy and healthy dietary patterns and periodontitis in adolescents (18–19 years of age). Materials and Methods: This population-based study (n = 2515) modelled direct and mediated pathways (via biofilm and obesity) from patterns of healthy diet (fruits, fibre, vegetables, and dairy) and unhealthy diet (sugars, snacks, and salty/fast foods) with initial periodontitis (bleeding on probing [BoP], probing depth [PD] ≥ 4 mm, clinical attachment loss [CAL] ≥ 4 mm), moderate periodontitis (BoP, PD ≥ 5 mm, and CAL ≥ 5 mm), and European Federation of Periodontology and the American Academy of Periodontology (EFP-AAP) periodontitis definitions, adjusting for sex, socio-economic status, smoking, and alcohol, through structural equation modelling (α = 5%). Results: Higher values of healthy diet were associated with lower values of initial periodontitis (standardized coefficient [SC] = −0.160; p <.001), moderate periodontitis (SC = −0.202; p <.001), and EFP-AAP periodontitis (p <.05). A higher value of unhealthy diet was associated with higher values of initial periodontitis (SC = 0.134; p =.005) and moderate periodontitis (SC = 0.180; p <.001). Biofilm mediated the association between higher values of unhealthy diet and all periodontal outcomes (p <.05). Conclusions: Our findings suggest that both healthy and unhealthy dietary patterns may contribute to reduced or increased extent and severity of periodontitis by local and systemic mechanisms, preceding the effect of other established causes such as smoking and obesity, in younger population.

Forskning Wed, 01 Jun 2022 21:35:15 +0200 5cd33f14-eeb7-408f-84eb-93f570e5181c
<![CDATA[A review on the application of deep learning for CT reconstruction, bone segmentation and surgical planning in oral and maxillofacial surgery]]> Minnema, J., Ernst, A., van Eijnatten, M., et al. Computer-assisted surgery (CAS) allows clinicians to personalize treatments and surgical interventions and has therefore become an increasingly popular treatment modality in maxillofacial surgery. The current maxillofacial CAS consists of three main steps: (1) CT image reconstruction, (2) bone segmentation, and (3) surgical planning. However, each of these three steps can introduce errors that can heavily affect the treatment outcome. As a consequence, tedious and time-consuming manual post-processing is often necessary to ensure that each step is performed adequately. One way to overcome this issue is by developing and implementing neural networks (NNs) within the maxillofacial CAS workflow. These learning algorithms can be trained to perform specific tasks without the need for explicitly defined rules. In recent years, an extremely large number of novel NN approaches have been proposed for a wide variety of applications, which makes it a difficult task to keep up with all relevant developments. This study therefore aimed to summarize and review all relevant NN approaches applied for CT image reconstruction, bone segmentation, and surgical planning. After full text screening, 76 publications were identified: 32 focusing on CT image reconstruction, 33 focusing on bone segmentation and 11 focusing on surgical planning. Generally, convolutional NNs were most widely used in the identified studies, although the multilayer perceptron was most commonly applied in surgical planning tasks. Moreover, the drawbacks of current approaches and promising research avenues are discussed.

Forskning Thu, 01 Sep 2022 21:35:15 +0200 213bfac5-54fb-4411-813c-e4b41332e8a0
<![CDATA[Behandlingsplanlægning før lateral genopbygning af processus alveolaris med henblik på implantatbehandling]]> Schropp, L., Jensen, S. S., Starch-Jensen, T. Formidling Sun, 01 May 2022 21:35:15 +0200 0d765c80-d99a-45f7-ae7f-5d417563b1d7 <![CDATA[Zygomatic repositioning and Le Fort II distraction with intraoral devices in Apert syndrome]]> Nørholt, S. E., Sköldstam, J., Blomlöf, J., Karunahara, S., Pedersen, T. K. The aim of this case report is to describe the surgical technique and outcome using internal intraoral distraction devices in LeFort II distraction with zygomatic repositioning (LF2ZR). In Apert syndrome the midface is characterized by a complex hypoplasia, with the central part being more affected than the lateral orbito-zygomatic complex. In LF2ZR, the zygomas are repositioned and internally fixated, and the central midface is further advanced through a LeFort II distraction. In previous publications, the distraction has been performed using external halo-based devices. It seems that the LF2ZR procedure can be planned and performed with adequate accuracy using virtual surgical planning tools. Knowledge about the possibility of using internal intraoral distraction devices in LF2ZR is important, as the inconspicuous placement of intraoral devices can be advantageous for some patients.

Forskning Fri, 01 Apr 2022 21:35:15 +0200 38b486bd-8609-48b1-9799-b2f51f6ef939
<![CDATA[Renaming burning mouth syndrome]]> Currie, C. C., Ohrbach, R., De Leeuw, R., et al. Forskning Sun, 01 May 2022 21:35:15 +0200 1fdf95b5-37b0-4442-9be7-0e67fa77fb7c <![CDATA[Intraglandular Off-the-Shelf Allogeneic Mesenchymal Stem Cell Treatment in Patients with Radiation-Induced Xerostomia]]> Lynggaard, C. D., Grønhøj, C., Christensen, R., et al. No effective therapy exists for the most common long-term side effect of radiation therapy for head and neck cancer (HNC)-xerostomia. The objective was to evaluate safety and provide proof of concept for efficacy of allogeneic adipose tissue-derived mesenchymal stem/stromal cells (AT-MSCs) injected into the major salivary glands of irradiated patients. This open-label, first-in-human, phase 1b, and single-center trial was conducted with repeated measurements days 0, 1, 5, and 30 and 4 months. Eligible patients with objective and subjective signs of radiation-induced salivary gland damage after treatment of oropharyngeal squamous cell carcinoma stages I-II (UICC 8) were enrolled. Twenty-five million cryopreserved AT-MSCs were injected into each submandibular and 50 million AT-MSCs into each parotid gland. Data were collected on adverse events, unstimulated and stimulated whole saliva (UWS and SWS) flow rates and saliva composition, patient-reported outcomes (EORTC QLQ-H&N35 and Xerostomia Questionnaire [XQ]), blood samples and salivary gland scintigraphy. Data were analyzed using repeated measures linear mixed models. Ten patients (7 men, 3 women, 59.5 years [range: 45-70]) were treated in 4 glands. No treatment-related serious adverse events occurred. During 4 months, UWS flow rate increased from 0.13 mL/minute at baseline to 0.18 mL/minute with a change of 0.06 \n(P = .0009) mL/minute. SWS flow rate increased from 0.66 mL/minute at baseline to 0.75 mL/minute with a change of 0.09 (P = .017) mL/minute. XQ summary score decreased by 22.6 units (P = .0004), EORTC QLQ-H&N35 dry mouth domains decreased by 26.7 (P = .0013), sticky saliva 23.3 \n(P = .0015), and swallowing 10.0 (P = .0016). Our trial suggests treatment of the major salivary glands with allogenic AT-MSCs is safe, warranting confirmation in larger trials.

Forskning Sun, 01 May 2022 21:35:15 +0200 c1154a10-f8b7-4d8a-9cec-0d3f8afc6672
<![CDATA[<i>In Vitro</i> Comparison of Different Invisalign® and 3Shape® Attachment Shapes to Control Premolar Rotation]]> Ferlias, N., Dalstra, M., Cornelis, M. A., Cattaneo, P. M. Aim: To evaluate in vitro the differences of various Invisalign® attachments in their effectiveness during derotation of an upper second premolar in terms of forces and moments created and compare them to the 3Shape® box attachment as well as to no attachment at all. Materials and Methods: A Force System Identification (FSI) machine, comprising two load sensors, was used in this study. Sensor 1 was connected to the test tooth (i.e. upper second premolar) carrying a different attachment design, and the fixed sensor (Sensor 2) was connected to the base model. Once the corresponding aligner was passively seated on the teeth, 12 different setups (i.e. 11 different attachments and one setup with no attachment at all) were tested by rotating the test tooth 4.5° mesially and 4.5° distally, in increments of 0.45°. Results: The vertical rectangular attachments were able to generate the highest derotational moment on both mesial and distal rotations but also received the most side effects (intrusive force, torque, and tipping). The no-attachment setup performed least favorably in terms of derotational ability but exhibited the least side effects. In the y-axis, all attachments received a buccal root torque with a lingual force during disto-rotation and a lingual root torque with a buccal force during mesio-rotation. Conclusion: Attachments are necessary for derotating an upper second premolar. An aligner incremental change of more than 1° derotation can generate high moments. The vertical rectangular attachments perform best in derotations; however, they exhibit the most side effects. Finally, despite presenting the least side effects, derotation of a premolar with no attachment is not as efficient.

Forskning Tue, 01 Mar 2022 21:35:15 +0100 210078da-160b-42c4-a40e-931bddd33bab
<![CDATA[Restricted upper airway dimensions in patients with dentofacial deformity from juvenile idiopathic arthritis]]> Niu, X., Moland, J., Pedersen, T. K., et al. Background: This retrospective, cross-sectional study aimed to assess the pharyngeal airway dimensions of patients with juvenile idiopathic arthritis (JIA) and moderate/severe JIA-related dentofacial deformity (mandibular retrognathia/micrognathia), and compare the results with JIA patients with a normal mandibular appearance and a group of non-JIA patients. Methods: Seventy-eight patients were retrospectively included in a 1:1:1 manner as specified below. All patients had previously been treated at the Section of Orthodontics, Aarhus University, Denmark. All had a pretreatment cone beam computed tomography (CBCT). Group 1 (JIA+); 26 JIA patients with severe arthritis-related dentofacial deformity and mandibular retrognathia/micrognathia. Group 2 (JIA-); 26 JIA patients with normal mandibular morphology/position. Group 3 (Controls); 26 non-JIA subjects. Dentofacial morphology and upper airway dimensions, excluding the nasal cavity, were assessed in a validated three-dimensional (3D) fashion. Assessment of dentofacial deformity comprised six morphometric measures. Assessment of airway dimensions comprised nine measures. Results: Five morphometric measures of dentofacial deformity were significantly deviating in the JIA+ group compared with the JIA- and control groups: Posterior mandibular height, anterior facial height, mandibular inclination, mandibular occlusal inclination, and mandibular sagittal position. Five of the airway measurements showed significant inter-group differences: JIA+ had a significantly smaller nasopharyngeal airway dimension (ad2-PNS), a smaller velopharyngeal volume, a smaller minimal cross-sectional area and a smaller minimal hydraulic diameter than JIA- and controls. No significant differences in upper airway dimensions were seen between JIA- and controls. Conclusion: JIA patients with severe arthritis-related dentofacial deformity and mandibular micrognathia had significantly restricted upper airway dimensions compared with JIA patients without dentofacial deformity and controls. The restrictions of upper airway dimension seen in the JIA+ group herein were previously associated with sleep-disordered breathing in the non-JIA background population. Further studies are needed to elucidate the role of dentofacial deformity and restricted airways in the development of sleep-disordered breathing in JIA.

Forskning Fri, 01 Apr 2022 21:35:15 +0200 1e31cfeb-d310-4ee3-bc73-f390719a7490
<![CDATA[The Effect of Symmetric and Asymmetric Loading of Frontal Segment with Two Curved Cantilevers]]> Bilinska, M., Dalstra, M. Cantilevers generate statically determined force systems. The frontal segment loading with symmetric and asymmetric cantilevers in a three-piece intrusion base arch can be used to correct midline asymmetry. Three types of 0.017″ × 0.025″ beta-titanium cantilevers: tip-back (TB), deep curve (DC), utility arch (UA) were tested on typodonts simulating intrusion of the maxillary anterior segment. Typodonts with symmetric and asymmetric cantilevers were scanned with intraoral scanner (3Shape, TRIOS, Copenhagen, Denmark) before (T0) and after (T1) the experiment, scans were superimposed using Mimics software (Materialise, Leuven, Belgium). Data were analysed with qualitative analysis. All cantilevers generated vertical and horizontal forces. For symmetric design, the DC and TB displayed intrusive force with retrusive component, UA intrusion and protrusion. The asymmetric cantilevers produced transverse displacement of anterior segment. DC created lateral, UA medial force, the anterior segment displacement was consistent with the used configuration. The movement of an anterior segment with TB is smaller compared to DC and UA. Symmetric cantilevers configurations can achieve simultaneous intrusion and retrusion or protrusion of the anterior segment. The asymmetric design with transversal force can clinically aid the correction of midline discrepancies. The effect of the cantilever configuration on delivered force direction was confirmed.

Forskning Fri, 01 Apr 2022 21:35:15 +0200 116aab10-c664-41e3-89d3-c83319c7bd91
<![CDATA[Mesenchymal stromal/stem cell therapy for radiation-induced salivary gland hypofunction in animal models]]> Jansson, P. M., Lynggaard, C. D., Carlander, A. F., et al. Background: Salivary gland (SG) hypofunction (objectively reduced saliva flow rate) and xerostomia (subjective sensation of dry mouth) are common and burdensome side effects of radiotherapy to the head and neck region. Currently, only sparse symptomatic treatment is available to ease the discomfort of xerostomia. The objective of this study is to assess the effect of mesenchymal stem cell (MSC) therapy on SG function after radiation-induced injury. Methods: This systematic review will include animal intervention studies assessing efficacy and safety of MSCs in treating radiation-induced SG hypofunction. The primary outcome is the effect of MSC administration on salivary flow rates (SFR), by comparing treated groups to control groups when available. Secondary outcomes are morphological and immunohistochemical effects as well as safety of MSC treatment. Electronic searches in MEDLINE (PubMed) and Embase databases will be constructed and validated according to the peer review of electronic search strategies (PRESS) and assessed by two independent researchers. Data from eligible studies will be extracted, pooled, and analyzed using random-effects models. Risk of bias will be evaluated with the Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) risk of bias tool. Discussion: Thus far, critical appraisal of MSC therapy as an effective treatment for SG hypofunction caused solely by radiation injury has not been conducted. A summary of the existing literature on preclinical studies concerning this issue can provide valuable information about effectiveness, mode of action, and safety, allowing further optimization of preclinical and clinical trials. Systematic review registration: PROSPERO CRD42021227336

Forskning Fri, 01 Apr 2022 21:35:15 +0200 2c0f1a8e-dc3b-405e-a218-db7969cd9fff
<![CDATA[Trusting the Dentist—Expecting a Leap of Faith vs. a Well-Defined Strategy for Anxious Patients]]> Moore, R. Forskning Thu, 07 Apr 2022 21:35:15 +0200 9865e6f9-d77d-4a15-a2bf-8c639fdd374f <![CDATA[Maximizing Student Clinical Communication Skills in Dental Education - A Narrative Review]]> Moore, R. Forskning Fri, 01 Apr 2022 21:35:15 +0200 81cdc254-ff71-4dc0-bf20-f4ce4abf18ab <![CDATA[Fracture resistance of endodontically treated maxillary incisors restored with single or bundled glass fiber-reinforced composite resin posts]]> Ranjkesh, B., Haddadi, Y., Krogsgaard, C. A., Schurmann , A. ., Bahrami, G. Forskning Fri, 01 Apr 2022 21:35:15 +0200 1e964744-8520-4a00-8f1f-9689e1725db3 <![CDATA[Craniofacial Growth from Pre- to Post-Adolescence in Humans]]> Maciejewska-Turek, A., Bilinska, M., Wellens, H. L. L., Fudalej, P. S. investigation was twofold: 1) to assess the association (covariation) between craniofacial shape pre- and
post-adolescence and 2) to evaluate if pre-adolescent craniofacial shape is related (covaries) with growth
magnitude and direction.
SUBJECTS AND METHOD: One hundred and fifty subjects (86 males, 64 females) untreated orthodontically
were selected from the AAOF Craniofacial Growth Legacy Collection. Each subject had cephalograms taken
before 9 (pre-adolescent stage) and after 15 years of age (post-adolescent). Fourteen curves comprising 123
points (10 fixed and 113 sliding semi-landmarks) comprehensively covering the craniofacial skeleton were
digitally traced on each cephalogram. Procrustes alignment, principal component analysis, two-block partial
least squares (2B-PLS) analysis, and regression analysis were done after sliding the semi-landmarks to
minimize bending energy.
RESULTS: The first 16 principal components (PCs) were non-trivial and explained 85.2 per cent of total shape
variability in the sample. PC1 depicted mainly variability in the vertical direction, PC2 represented mostly
variability in the saddle angle and in the antero-posterior position of the mandible, and PC3 depicted
primarily variability of the mandibular shape (steep versus flat mandibular plane). The covariation between
pre- and post-adolescent facial shape was statistically significant, both in the pooled sample (RV coefficient
= 0.604) and in boys (RV = 0.639) and girls (RV = 0.629). The pre-adolescent shape was weakly associated
with the magnitude of facial change - 2Block-PLS analysis demonstrated that blocks 1 and 2 were
independent (P = 0.118, RV = 0.035); on the other hand, regression analysis showed that gender was the
strongest predictor of the magnitude of shape change (P = 0.001, r2 = 0.108) followed by PC4 (P = 0.015, r2
= 0.039) and PC7 (P = 0.018, r2 = 0.024).
CONCLUSIONS: The pre-adolescent shape of the craniofacial complex explained approximately 60 per cent
of the post-adolescent shape of the craniofacial complex; however, the relationship between preadolescent
shape of the craniofacial complex and magnitude of its change was weak.]]>
Forskning Fri, 01 Oct 2021 21:35:15 +0200 72079da8-d746-448b-9cd0-1229b17e462b
<![CDATA[Status of Retained Primary Second Molars and Congenital Absence of Second Premolars in Relation to Age -]]> Bilinska, M., Zadurska, M. ., Czochrowska, E. M. . the congenital absence of second premolars (PM2) in relation to age.
MATERIALS AND METHOD: Panoramic radiographs of individuals above 10 years of age with agenesis of at
least one PM2 were evaluated. Patients were divided into three groups according to age: 10-13 years, 14-17
years and 18-22 years. The study group was examined for the presence and location of retained DM2, the
presence of caries/restorations, infraocclusion and root resorption.
RESULTS: A total of 131 subjects with PM2 agenesis were included, 82 females (62.6%) and 49 males
(37.4%) aged 10-22 years (mean age: 13 years 11 months). The majority were missing one or two PM2. PM2
agenesis occurred three times more frequently in the mandible than in the maxilla. In all, 174 retained DM2
were present (33%) and their incidence was higher in the younger age groups. In all age groups, the majority
of the DM2 were retained in the mandible (79%). Caries/restorations were found in 88 (50.6%) and
infraocclusion in 21 (12%) retained DM2. The roots were resorbed mostly in half of the root length (35%).
CONCLUSIONS: Long-term survival of DM2 with PM2 agenesis is uncertain, especially at a younger age. In
individuals older than 17 years, the prognosis for a healthy DM2 seems favourable, if no distinct
infraocclusion or extensive root resorption is present.]]>
Forskning Fri, 01 Oct 2021 21:35:15 +0200 8e52e887-1448-44cc-a62e-54fbd0804292
<![CDATA[Effect of data binning and frame averaging for micro-CT image acquisition on the morphometric outcome of bone repair assessment]]> Irie, M. S., Spin-Neto, R., Borges, J. S., Wenzel, A., Soares, P. B. F. Despite the current advances in micro-CT analysis, the influence of some image acquisition parameters on the morphometric assessment outcome have not been fully elucidated. The aim of this study was to determine whether data binning and frame averaging affect the morphometric outcome of bone repair assessment using micro-CT. Four Wistar rats’ tibiae with a surgically created bone defect were imaged with micro-CT six times each, frame averaging set to 1 and 2, and data binning set to 1, 2 and 4, for each of the averaging values. Two-way ANOVA followed by Bonferroni tests assessed the significance of frame averaging and data binning on a set of morphometric parameters assessed in the image volumes (p < 0.01). The effect of frame averaging was not significant for any of the assessed parameters. Increased data binning led to larger trabecular thickness. In contrast, smaller bone volume fraction and bone volume were found as data binning increased. Trabeculae number and trabecular separation were not influenced by any of the parameters. In conclusion, the morphometric outcome of bone repair assessment in micro-CT demonstrated dependency upon data binning, but not frame averaging. Therefore, image acquisition of small anatomical structures (e.g., rat trabeculae) should be performed without data binning.

Forskning Sat, 01 Jan 2022 21:35:15 +0100 9c72eb05-faf9-4e46-a5bd-24ca50e1809a
<![CDATA[Temporomandibular disorders cases with high-impact pain are more likely to experience short-term pain fluctuations]]> Herrero Babiloni, A., Exposto, F. G., Peck, C. M., et al. Temporomandibular disorders (TMD) patients can present clinically significant jaw pain fluctuations which can be debilitating and lead to poor global health. The Graded Chronic Pain Scale evaluates pain-related disability and its dichotomous grading (high/low impact pain) can determine patient care pathways and in general high-impact pain patients have worse treatment outcomes. Individuals with low-impact TMD pain are thought to have better psychosocial functioning, more favorable disease course, and better ability to control pain, while individuals with high-impact pain can present with higher levels of physical and psychological symptoms. Thereby, there is reason to believe that individuals with low- and high-impact TMD pain could experience different pain trajectories over time. Our primary objective was to determine if short-term jaw pain fluctuations serve as a clinical marker for the impact status of TMD pain. To this end, we estimated the association between high/low impact pain status and jaw pain fluctuations over three visits (≤ 21-day-period) in 30 TMD cases. Secondarily, we measured the association between jaw pain intensity and pressure pain thresholds (PPT) over the face and hand, the latter measurements compared to matched pain-free controls (n = 17). Jaw pain fluctuations were more frequent among high-impact pain cases (n = 15) than low-impact pain cases (n = 15) (OR 5.5; 95% CI 1.2, 26.4; p value = 0.033). Jaw pain ratings were not associated with PPT ratings (p value > 0.220), suggesting different mechanisms for clinical versus experimental pain. Results from this proof-of-concept study suggest that targeted treatments to reduce short-term pain fluctuations in high-impact TMD pain is a potential strategy to achieve improved patient perception of clinical pain management outcomes.

Forskning Sat, 01 Jan 2022 21:35:15 +0100 7b6a89aa-0731-4a28-9175-33243f4ecbc9
<![CDATA[What is the nocebo effect and does it apply to dentistry?]]> Watanabe, T., Sieg, M., Lunde, S. J., et al. Evidence for the nocebo effect, a phenomenon characterised by suboptimal treatment efficacy, worsening of symptoms, or the occurrence of adverse events caused by an individual's negative treatment expectations, is growing across a multitude of medical fields. Within dentistry, little attention has been paid to patients' negative expectations, despite a number of studies supporting the influence of related factors, such as dental fear and anxiety, on the severity of peri- and post-operative dental pain. Only recently, a small number of commentaries and letters have emerged, urging dentists to recognise the possible existence of nocebo effects in dentistry and its implications for patient care. The present review summarises essential evidence of the nocebo phenomenon especially in relation to pain and drug administration. Subsequently, an overview of the current evidence of the nocebo phenomenon in the dental field is presented. Finally, based on the general knowledge of the nocebo effect, the review indicates fruitful arrays of research into the nocebo effect in dentistry.

Forskning Sun, 01 May 2022 21:35:15 +0200 ffa04901-bdea-433b-92b2-a6327ce4263a
<![CDATA[Oral Complications of Cancer Therapies]]> Jensen, S. B., Saunders, D. P. Undervisning Thu, 01 Jul 2021 21:35:15 +0200 121aa724-143a-42a8-8fb6-70725b5e6e74 <![CDATA[Oral complications of nonsurgical cancer therapies]]> Jensen, S. B., Peterson, D. E. Undervisning Tue, 01 Jun 2021 21:35:15 +0200 759c90dc-a237-4ada-b78e-44a49aa6aebc <![CDATA[A quantitative bias analysis to assess the impact of unmeasured confounding on associations between diabetes and periodontitis]]> Raittio, E., Nascimento, G. G., Shamsoddin, E., Ashraf, J. Forskning Sat, 01 Jan 2022 21:35:15 +0100 ea412893-d4ad-479b-ad62-a03c61c37a3f <![CDATA[Survival of atraumatic restorative treatment restorations in the elderly patients]]> Maia, T. S., Lima, T. D., Vieira, W. d. A., et al. This study aimed to assess the survival of glass ionomer cement (GIC) restorations performed using the atraumatic restorative treatment (ART) in elderly patients. The systematic review protocol was registered in the PROSPERO database. The records were searched until August 2020 in eight electronic bibliographic databases, and included randomized and non-randomized clinical trials and observational studies, with no restrictions on the language or year of publication. Study selection and data extraction were performed independently by two reviewers. Data were extracted, summarized, collected for qualitative analysis, and evaluated for individual risk of bias using the Joanna Briggs Institute's Critical Appraisal Tool. The literature search retrieved 5,186 records; however, only seven studies fulfilled the eligibility criteria and were included. The studies were published between 2002 and 2019. A total of 1,239 restorations were investigated at intervals of 6, 12, 24, and 60 months of follow-up. Some studies had a low risk of bias, while others had moderate and high risk of bias. In general, GIC restorations placed using ART were considered satisfactory. The 6-month, 12-month, and 24-month survival rates ranged from 81.3% to 97.2%, 72.2% to 94%, and 63% to 87%, respectively; additionally, the survival rate for the longest follow-up period (60 months) was 85%. Given the best evidence-based information regarding caries removal, we highlight the need to provide a conservative and effective technique for use in elderly patients. ART is a promising and viable alternative that guarantees the survival of restorations in elderly patients.

Forskning Fri, 01 Jan 2021 21:35:15 +0100 77239a0c-593a-46db-9e74-5b305631327b
<![CDATA[Scoping Review of Oral Health-Related Birth Cohort Studies]]> Peres, K. G., Nascimento, G. G., Gupta, A., Singh, A., Cassiano, L. S., Rugg-Gunn, A. J. The multidisciplinary nature and long duration of birth cohort studies allow investigation of the relationship between general and oral health and indicate the most appropriate stages in life to intervene. To date, the worldwide distribution of oral health-related birth cohort studies (OHRBCSs) has not been mapped, and a synthesis of information on methodological characteristics and outcomes is not available. We mapped published literature on OHRBCSs, describing their oral health-related data and methodological aspects. A 3-step search strategy was adopted to identify published studies using PubMed, Embase, Web of Science, and OVID databases. Studies with baseline data collection during pregnancy or within the first year of life or linked future oral health data to exposures during either of these 2 life stages were included. Studies examining only mothers' oral health and specific populations were excluded. In total, 1,721 articles were suitable for initial screening of titles and abstracts, and 528 articles were included in the review, identifying 120 unique OHRBCSs from 34 countries in all continents. The review comprised literature from the mid-1940s to the 21st century. Fifty-four percent of the OHRBCSs started from 2000 onward, and 75% of the cohorts were from high-income and only 2 from low-income countries. The participation rate between the baseline and the last oral health follow-up varied between 7% and 93%. Ten cohorts that included interventions were mostly from 2000 and with fewer than 1,000 participants. Seven data-linkage cohorts focused mostly on upstream characteristics and biological aspects. The most frequent clinical assessment was dental caries, widely presented as decayed, missing, and filled teeth (DMFT/dmft). Periodontal conditions were primarily applied as isolated outcomes or as part of a classification system. Socioeconomic classification, ethnicity, and country- or language-specific assessment tools varied across countries. Harmonizing definitions will allow combining data from different studies, adding considerable strength to data analyses; this will be facilitated by forming a global consortium.

Forskning Wed, 01 Jun 2022 21:35:15 +0200 b3519354-be26-41d0-b996-164aecafa0e3
<![CDATA[Sådan behandler du tænder med horisontal rodfraktur]]> Kruse, C., Markvart, M. ., Klausen, B. . Forskning Mon, 01 Mar 2021 21:35:15 +0100 1a90338b-cf65-4494-b000-eceabd2b3120 <![CDATA[Endodonti]]> Kruse, C., Kirkevang, L. Undervisning Fri, 01 Jan 2021 21:35:15 +0100 27449422-ca3a-4d48-a44b-331ecd6162f0 <![CDATA[Facilitatory Effect of Intermittent Repetitive Transcranial Magnetic Stimulation on Perceptual Distortion of the Face]]> Kothari, S. F., Blicher, J., Dagsdóttir, L. K., et al. Forskning Wed, 01 Jun 2022 21:35:15 +0200 1dc49c6c-57ee-4c65-9556-0b618c9bab1b <![CDATA[Soft and hard tissue procedures, including dental extractions]]> Taneja, P. Undervisning Sat, 01 May 2021 21:35:15 +0200 1cd1a645-1b45-4836-b70c-f51cf590ed6d <![CDATA[Medical Emergencies]]> Tagesen, J., Taneja, P. Undervisning Sat, 01 May 2021 21:35:15 +0200 3a637bb5-db11-43f9-b8dc-516a78deb273 <![CDATA[Artefacts in sensor-based cephalograms and the effect of head movement]]> Svystun, O. Forskning Wed, 01 Sep 2021 21:35:15 +0200 7ed0668f-b9ee-42ed-abec-370af923b486 <![CDATA[Robotic stroking on the face and forearm]]> Taneja, P., Baad-Hansen, L., Shaikh, S., Svensson, P., Olausson, H.
Methods: A total of 24 participants were recruited and randomized to receive continuous stroking, utilizing a robotic stimulator, at C-tactile (CT) favorable (3 cm/s) and non-favorable (30 cm/s) velocities applied to the right face or forearm. Ratings of touch pleasantness and unpleasantness and PPTs from the hypothenar muscle of the right hand were collected at the start of stroking and once per minute for 5 min.

Results: A reduction in PPTs (increased pain sensitivity) was observed over time (P < 0.001). However, the increase in pain sensitivity was less prominent when the face was stroked compared to the forearm (P = 0.001). Continuous stroking resulted in a significant interaction between region and time (P = 0.008) on pleasantness ratings, with a decline in ratings observed over time for the forearm, but not on the face. Unpleasantness ratings were generally low.

Conclusion: We observed touch satiety for 5 min of continuous robotic brushing on the forearm confirming previous studies. However, we did not observe any touch satiety for brushing the face. Mechanical pain sensitivity, measured in the hand, increased over the 5-min period but less so when paired with brushing on the face than with brushing on the forearm. The differential effects of brushing on the face and forearm on touch satiety and pain modulation may be by the differences in the emotional relevance and neuronal pathways involved.]]>
Forskning Mon, 01 Nov 2021 21:35:15 +0100 db4f5270-2319-41e2-84d6-d2b676d8fc07
<![CDATA[Trends of endodontic and periapical status in adult Danish populations from 1997 to 2009]]> Razdan, A., Jungnickel, L., Schropp, L., Væth, M., Kirkevang, L. AIM: To compare the endodontic and periapical status of two similar adult Danish populations examined in 1997-1998 and 2007-2009, respectively.

METHODOLOGY: Two populations from Aarhus County, Denmark (age range: 20-64 years) were randomly selected using the Danish Civil Registration System. Full-mouth intraoral radiographs (14 periapical, 2 bitewing) of 616 individuals in 1997-1998 (C1: 16 018 teeth) and 398 individuals in 2007-2009 (C2: 10 668 teeth) were taken to ascertain the number of teeth, presence of root fillings (RFs) and apical periodontitis (AP) using the periapical index (PAI). T-tests with unequal variances were used to assess differences between C1 and C2 with respect to age and the number of teeth. Multivariable and multinomial logistic regression analyses were used to assess the effect of cohort, age and tooth type on the prevalence and relative frequency of RFs and AP.

RESULTS: Mean age and mean number of teeth were higher in C2 than C1 (age; C1: 42.3 years, C2: 44.6 years; p = .003), (teeth; C1: 26.0, C2: 26.8; p < .001). The prevalence of root filled teeth was lower in C2 than C1 (C1: 51.8%, C2: 45.0%; p = .03); however, the prevalence of AP was similar (C1: 42.0%, C2: 45.0%). The relative frequency of root filled teeth was lower in C2 than C1 (C1: 4.8%, C2: 3.6%; p = .004), although the individuals were older in C2. The relative frequency of AP was similar in the two cohorts (C1: 3.3%, C2: 3.6%; p = .42). The relative frequency of AP in non-root filled teeth doubled from 0.9% in C1 to 1.8% in C2. C2 had higher PAI scores than C1 for root filled and non-root filled teeth, despite age correction (p ≤ .0007).

CONCLUSIONS: Two similar general Danish populations examined, respectively, in 1997-1998 and 2007-2009, were associated with a decreasing trend in the prevalence and relative frequency of RFs over the decade. There was no difference in relative frequency of AP in root filled teeth, but an increase in relative frequency of AP in non-root filled teeth. Further population-based studies including analysis of non-root filled teeth using the full-scale PAI and quality assessment of restorations are recommended.

Forskning Tue, 01 Feb 2022 21:35:15 +0100 819f0ccd-e269-4625-8560-d201233c2bde
<![CDATA[Ratiometric analysis of local S. mutans biofilm pH on tooth and restoration surfaces.]]> Schlafer, S., Bornmann, T., Paris, S., Göstemeyer, G. Forskning Thu, 01 Jul 2021 21:35:15 +0200 30c8470e-d752-481f-8cf8-a1d104d36ddb