Publications - Publications en-us PURE Extension (Web Department) 30 <![CDATA[Intraglandular mesenchymal stem cell treatment induces changes in the salivary proteome of irradiated patients]]> Lynggaard, C. D., Jersie-Christensen, R., Juhl, M., et al. BACKGROUND: Hyposalivation and xerostomia (dry mouth), are the leading site-effects to treatment of head and neck cancer. Currently, there are no effective therapies to alleviate radiation-induced hyposalivation. Adipose tissue-derived mesenchymal stem/stromal cells (AT-MSCs) have shown potential for restoring salivary gland function. However, the mode of action is unknown. The purpose of the present study was therefore to characterize the effect of AT-MSC therapy on the salivary proteome in previously irradiated head and neck cancer patients.

METHODS: Whole saliva was collected from patients with radiation-induced salivary gland hypofunction (n = 8) at baseline, and 120 days after AT-MSC treatment, and from healthy controls (n = 10). The salivary proteome was characterized with mass spectrometry based proteomics, and data was compared within the AT-MSC group (baseline versus day 120) and between AT-MSC group and healthy controls. Significance levels between groups were determined by using double-sided t-test, and visualized by means of principal component analysis, volcano plots and cluster analysis.

RESULTS: Here we show that 140 human proteins are significantly differentially expressed in saliva from patients with radiation-induced hypofunction versus healthy controls. AT-MSC treatment induce a significant impact on the salivary proteome, as 99 proteins are differentially expressed at baseline vs. 120 days after treatment. However, AT-MSC treatment does not restore healthy conditions, as 212 proteins are significantly differentially expressed in saliva 120 days after AT-MSCs treatment, as compared to healthy controls.

CONCLUSION: The results indicate an increase in proteins related to tissue regeneration in AT-MSCs treated patients. Our study demonstrates the impact of AT-MSCs on the salivary proteome, thereby providing insight into the potential mode of action of this novel treatment approach.

Research Thu, 01 Dec 2022 12:54:18 +0100 eeefb48a-5a57-4f1f-aed3-cc31af4cf376
<![CDATA[Dietary vitamin D and calcium and periodontitis]]> Nascimento, G. G., Leite, F. R.M., Gonzalez-Chica, D. A., Peres, K. G., Peres, M. A. Aim: This study aimed to explore the relationship between dietary vitamin D and calcium intake and periodontitis among adults and whether it differs from males to females. Methods: Cross-sectional analysis of a population-based cohort study with adults aged 20 to 60 from Southern Brazil. Intake of vitamin D and calcium were gathered in 2012 using two 24h-dietary recalls. Clinical examination assessed the clinical attachment level and bleeding on probing. Confounders included sex, age, family income, smoking, and obesity. The controlled direct effect of vitamin D and calcium on periodontitis was examined using marginal structural modeling. Analyses were also stratified by sex. Results: Of the 1,066 investigated adults (mean age 35 ± 11.7 years; 49% females), 12.3% (95%CI 10.2;14.7) had periodontitis. Calcium intake had a direct protective effect on periodontitis (risk ratio (RR) 0.61; 95%CI 0.45;0.83), whereas no association between vitamin D and periodontitis was observed (RR 1.13; 95%CI 0.82;1.56). Stratified analyses revealed a null association between both vitamin D and calcium intake and periodontitis among men, but a protective association between calcium and intake and periodontitis among women (RR 0.56; 95%CI 0.38;0.79), while vitamin D remained without any association (RR 1.07; 95%CI 0.72;1.61). Conclusion: Our findings suggest a protective association between dietary calcium intake and periodontitis among women.

Research Thu, 01 Dec 2022 12:54:18 +0100 072e9034-509b-428e-a8a9-3dcb1d58ec52
<![CDATA[Effects of Calcium Hydroxide Intracanal Medications on T Helper (Th1, Th2, Th9, Th17, and Tfh) and Regulatory T (Treg) Cell Cytokines in Apical Periodontitis]]> Teixeira, F. F.C., Cardoso, F. G.R., Ferreira, N. S., et al. Introduction: This Consolidated Standards of Reporting Trials randomized clinical trial investigated T helper (Th1, Th2, Th9, Th17, and Tfh) and regulatory T (Treg) cell–type cytokines and their networks in apical periodontitis (AP). We also assessed the effects of calcium hydroxide [Ca(OH)2] intracanal medications (ICMs) on helper T and Treg cell–type cytokines. Methods: Twenty teeth with primary endodontic infection and apical periodontitis were randomly divided into two groups: Ca(OH)2 + saline solution (n = 10) and Ca (OH)2 + 2% chlorhexidine-gel (n = 10). Samples were collected from the periradicular tissue fluid (PTF) before (PTFs1) and after 14 days of ICMs (PTFs2). The Human High Sensitivity T Cell Panel was used to quantify target T-helper (Th)1: interelukin (IL)-2, IL-12, and interferon-gamma (IFN-γ); Th2: IL-4, IL-5, and IL-13; Th9: IL-9; Th17: IL-17; T follicular helper cells (Tfh): IL-21; and Treg-cell-type cytokine: IL-10. Results: Th1-type cytokines were higher than Th2-type ones, at PTFs1. Positive (+) associations were found among all Th1-type cytokines and all Th2-type cytokines. There were negative (-) correlations between all Th1- and Th2-type cytokines. Size of radiolucent lesions and symptoms (tenderness to percussion and/or pain on palpation) were positively correlated with Th1-type cytokines, IL-17, and IL-21 but negatively correlated with Th2-type cytokines and IL-10 (all, P <.001). Both ICMs increased Th2-type cytokines and IL-10 (P <.05) and decreased Th1-type cytokines, IL-17, and IL-21 (P <.05), with no differences among them (P >.05). Conclusions: Complex T-cell cytokine networks are involved in AP. Both Ca(OH)2 ICMs effectively increased IL-4, IL-5, IL-10, and IL-13 and lowered IL-2, IL-12, IL-17, IL-21, and IFN-γ.

Research Mon, 01 Aug 2022 12:54:18 +0200 54048af1-738b-48de-aceb-a7cd49e4be68
<![CDATA[Impacts of using orthodontic appliances on the quality of life of children and adolescents]]> Vidigal, M. T. C., Mesquita, C. M., de Oliveira, M. N., et al. BACKGROUND: Although there are previous systematic reviews about the oral health-related quality of life (OHRQoL) impact among children and adolescents after orthodontics treatment, there is no definition for the magnitude of these impacts during the therapy. OBJECTIVE: To systematically analyse the literature on changes in the quality of life of children and adolescents during orthodontic treatment. LIMITATIONS: Almost all the studies included in this review are non-randomized clinical trials, which are susceptible to several biases that affect the certainty of evidence obtained, especially by confounding factors and the lack of a control group. CONCLUSIONS AND IMPLICATIONS: Based on very low certainty of evidence, wearing appliances does not seem to have a significant negative impact during the first year of orthodontic treatment. However, the meta-analytic results suggest that functional limitations in the first 3 months of treatment can be slightly more critical for the impact on the oral health quality of life and consequent patient adherence to treatment. FUNDING: This study was financed by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico - Brazil (CNPq), and Fundação de Amparo à Pesquisa do Estado de Minas Gerais - Brazil (FAPEMIG). REGISTRATION: CRD42021234407.

Research Mon, 01 Aug 2022 12:54:18 +0200 57ba5ede-4bd1-4bd9-a4d1-19b92bd2794f
<![CDATA[Pharyngeal airway changes five years after bimaxillary surgery – A retrospective study]]> Madhan, S., Holte, M. B., Diaconu, A., et al. The aim of this study was to retrospectively evaluate pharyngeal airway (PA) changes after bimaxillary surgery (BMS). Preoperative, immediate- and 5-year postoperative cone-beam computed tomography images of subjects who underwent BMS were assessed. The primary outcome variable was the PA volume. The secondary outcome variables were the retropalatal and oropharyngeal volumes, cross-sectional area, minimal hydraulic diameter, soft tissue, skeletal movements and sleep-disordered breathing (SDB). A total of 50 patients were included, 33 female and 17 male, with a mean age of 26.5 years. A significant increase in the PA volume was seen immediately after surgery (40%), and this increase was still present at 5-year follow-up (34%) (P < 0.001). A linear mixed model regression analysis revealed that a mandibular advancement of ≥5 mm (P = 0.025) and every 1-mm upward movement of epiglottis (P = 0.016) was associated with a volume increase of the oropharyngeal compartment. Moreover, ≥5-mm upward movement of hyoid bone (P = 0.034) and every 1-mm increase in minimal hydraulic diameter (P < 0.001) correlated with an increase of the PA volume. A total of 30 subjects reported improvement in the SDB at 5-year follow-up. This study demonstrated that BMS led to an increase in PA dimensions in non-OSA patients, and these changes were still present at 5-year follow-up. BMS seemed to induce clinical improvement in SDB.

Research Tue, 01 Nov 2022 12:54:18 +0100 37389662-1477-49df-8356-563120298cc6
<![CDATA[Root-filled teeth in two parallel danish cohorts. A repeated coort study]]> Razdan, A., Schropp, L., Væth, M., Kirkevang, L. Research Sat, 01 Jan 2022 12:54:18 +0100 0b6b13e0-9d75-421b-8c80-1da7e41db142 <![CDATA[Root-filled teeth in two parallel Danish cohorts. A repeated cohort study]]> Razdan, A., Schropp, L., Væth, M., Kirkevang, L. Research Sat, 01 Jan 2022 12:54:18 +0100 62ed9b66-bd7c-4496-b01e-32ae3ee2d0ae <![CDATA[Pulpanekrose og apikal parodontitis]]> Markvart, M., Kruse, C., Andreasen, K. Research Sat, 01 Jan 2022 12:54:18 +0100 0049441b-024a-49aa-b287-40456f806d87 <![CDATA[Kæbeledsinvolvering ved juvenil idiopatisk artritis]]> Stoustrup, P. B., Lerman, M. A., Twilt, M. behandling af JIA bør også inddrage overvejelser om kæbeleddets tilstand, hvorfor tandlægens kendskab til tilstanden er vigtig. Undersøgelser tyder på,
at systemiske behandlinger nedsætter inflammationen i kæbeleddet og kan begrænse udvikling af dentofaciale deformiteter på langt sigt. Lokal
intraartikulær injektion med kortikosteroider kan anvendes med forsigtighed men bør så vidt muligt undgås ved skeletalt umodne patienter. Det tilrådes
at anvende ortodontisk apparatur (Distraktionsskinne) ved behandling af JIA-patienter i vækst. Kirurgisk behandling er en mulighed for patienter
med alvorlige dentofaciale deformiteter. Den optimale håndtering af JIA-associeret kæbeledsartritis bør ske ved en koordineret indsats af et tværfagligt
team, som omfatter børnereumatologer, radiologer, ortodontister, kæbekirurger, fysioterapeuter og andet relevant tandplejeteam.]]>
Communication Thu, 01 Sep 2022 12:54:18 +0200 c6f982fb-159d-410f-8289-99c143bac1a5
<![CDATA[Patientskader i forbindelse med ortodonti]]> Stoustrup, P. B., Ferlias, N. Communication Thu, 01 Sep 2022 12:54:18 +0200 0d962ca8-edd0-4f21-afea-a8312c066ead <![CDATA[Ansvarsplacering for ortodontibehandling i privat praksis]]> Bockhoff, M., Borchorst, M. U. Med et oplyst grundlag forstås:
• den foreslåede behandlings opnåelige mål, bivirkninger, komplikationer og prognose
• alternativer, også dem, man ikke selv kan forestå, men henviser for
• oplysning om, hvorvidt den foreslåede behandling forhindrer en eventuel senere udførelse af en alternativ behandlingsoption.
Enkeltstående tandflytninger eller tandflytninger alene i én kæbe har altid en indflydelse på den orale funktion; indflydelsen vil hyppigt være af negativ
karakter, hvis ikke såvel forankring som funktion omhyggeligt vurderes i planlægningsfasen. En behandlingsplan uden disse overvejelser vil afstedkomme en kompromisbehandling og skal være fremlagt som en sådan for patienten.
En del af de ortodontiske behandlingssystemer, der er til rådighed i tandlægebranchen, tilbyder en behandlingsplanlægning uden tandlægens interaktion, men uagtet hvilken teknologi der anvendes til planlægning og behandling, er det den behandlende tandlæge, der har ansvaret.]]>
Communication Mon, 01 Aug 2022 12:54:18 +0200 ae191f47-308e-4967-af1d-804b583d3141
<![CDATA[Operating time for wire ligation with self-ligating and conventional brackets]]> Cattaneo, P. M., Tepedino, M., Hansen, E. B., Gram, A. R., Cornelis, M. A. Objective: Operating time is one of the main advantages attributed from the literature to the use of self-ligating brackets (SLB). The aim of this study is to investigate the time needed for a complete archwire change procedure with conventional brackets (CB) and SLBs in a standardized in vitro research setting, comparing operators with different expertise. Materials and Methods: Thirty-three participants were divided into three equal groups: undergraduate students, postgraduate students, and orthodontists. Three sets of typodonts bonded with three types of brackets, including passive SLBs, active SLBs, and CBs using both steel and elastic ligatures were investigated. Operators had to insert, ligate, deligate, and remove wires in sets of typodonts representing an actual dentition before and after orthodontic treatment, mounted in phantoms. Archwire change procedure times were compared between the different bracket/ligation systems, between the before- and after-treatment typodonts, and between operators. Results: There were significant differences between SLBs and CBs, the greatest difference being 11 min 16 s between passive SLBs and CBs ligated with metallic ligatures at T0, for the total archwire change procedure by the operators overall. For all the operators, there was a statistically significant difference in total archwire change procedure time between the systems. The undergraduate students were the slowest when using CBs, but they showed no significant difference compared to the other users when using SLBs. Conclusion: SLBs can offer a significant operating time reduction compared to CBs, and time saving is not dependent on the operator's experience and training.

Research Thu, 01 Dec 2022 12:54:18 +0100 49b64d57-5b18-4c20-9dbd-0daf987dec5a
<![CDATA[Early detection of external cervial resorption in posterior teeth:]]> Villefrance, J. S., Wenzel, A., Kirkevang, L., Væth, M., Matzen, L. H. Research Sat, 01 Jan 2022 12:54:18 +0100 bc2c600a-b952-4b35-91c3-9c9797c79ce2 <![CDATA[Obstructive sleep apnoea in pycnodysostis]]> Ferlias, N., Gjørup, H., Doherty, M. A., Haagerup, A., Pedersen, T. K. Research Mon, 01 Aug 2022 12:54:18 +0200 05f3a88b-ff79-40c4-b3c1-f6bd8af5f98b <![CDATA[Peri-implantitis progression in different implant designs:]]> Pessoa, R., Sousa, R., Pereira, L., et al. Research Thu, 01 Sep 2022 12:54:18 +0200 b9ba8c9b-72be-40da-a011-c276876e3cc4 <![CDATA[Impact of horizontal and vertical implant position on the radiographic marginal bone level]]> Kjelde, A., Gotfredsen, K., Storgaard Jensen, S., Spin-Neto, R. Research Thu, 01 Sep 2022 12:54:18 +0200 33f09583-2df7-49c7-a65d-036b9a75f4a1 <![CDATA[Online search interest in the use of antibiotics for dental pain]]> Roxo-Gonçalves, M., Bitencourt, F. V., Azevedo, C. B., Fiorini, T., Carrard, V. C. Objective: The objective of this study was to evaluate the online search interest pertaining to queries regarding antibiotics for dental pain. Material and Methods: Google Trends™ was used to identify the online search interest. Previously, a literature search was performed on the most frequently used antibiotics in dentistry in Brazil. Accordingly, the search terms used were Amoxicillin (AM), Clindamycin (CD), Azithromycin (AZ) and Metronidazole (MD), with the phrase “for toothache” in Portuguese and English. A time-series covered the last 240 weeks (from 2015 to 2020), and the results of each term were compared to their respective annual value. Geographic regions were also evaluated. To obtain a relative search volume (RSV), the resulting Google Trends™ numbers were then scaled to a range from 0 to 100 based on the ratio of searches on a topic to searches across all topics. Results: We observed an upward trend in all antibiotics search terms over the 5 years analyzed, with a peak of greater interest in 2019. The antibiotic of most interest related to toothache was ‘AM’, followed by ‘AZ’, ‘MD’, and ‘CD’. The annual RSV of toothache searches rose steadily from 2015 to 2020. Variations were observed between Brazilian geographic regions, and the Northeast region presented with the greatest interest in the topic. Conclusion: Although there were variations in annual and regional trends, an expressive and persistent increase in collective interest regarding the use of antibiotics related to toothache, mainly amoxicillin, was observed. Our findings provide insights for public health promotion programs.

Research Fri, 01 Jul 2022 12:54:18 +0200 48355a94-71c7-443b-b73c-140e40052e49
<![CDATA[Periodontitis Is Associated with Consumption of Processed and Ultra-Processed Foods]]> Cassiano, L. S., Peres, M. A., Motta, J. V.S., et al. The association between periodontitis and lifestyle factors has been widely investigated. However, an association between periodontitis and dietary patterns has not been explored. Therefore, this study investigated the association between periodontitis and food consumption among a Southern Brazil population. Data from the 1982 Pelotas Birth Cohort were used (n = 537). The exposure, periodontitis, was clinically measured and classified using the AAP/CDC system, then two latent variables were defined: ‘initial’ and ‘moderate/severe’ periodontitis. The consumption of in natura, processed, and ultra-processed foods (NOVA classification) was the outcome and measured in calories using the food frequency questionnaire (FFQ). Confounders were sex, maternal education, smoking status, xerostomia, and halitosis. Data were analyzed by structural equation modeling. ‘Initial’ periodontitis was associated with a higher consumption of in natura food (standardized coefficient (SC) 0.102; p-value = 0.040), versus processed (SC 0.078; p-value = 0.129) and ultra-processed (SC 0.043; p-value = 0.400) foods. ‘Moderate/severe’ periodontitis was associated with higher consumption of ultra-processed foods (SC 0.108; p-value = 0.024), versus processed (SC 0.093; p-value = 0.053) and in natura (SC 0.014; p-value = 0.762) foods. ‘Moderate/severe’ periodontitis appears to be associated with the consumption of processed and ultra-processed foods.

Research Thu, 01 Sep 2022 12:54:18 +0200 e90c0890-dbf8-49a1-ace5-8e22cc469973
<![CDATA[Location of mechanically-evoked referred sensations within the trigeminal region are not altered following a heterotopic painful stimulus]]> Exposto, F. G., Huang, M., Haasnoot, T., et al. To investigate whether the location, area and frequency of referred sensations occurring during palpation of the masseter muscle can be influenced by application of a conditioning painful stimulus to the temporalis muscle. Thirty healthy participants were included in this cross-over study, performed in two sessions with > 48 h in between. At each session, palpation of the masseter muscle was performed before and after 0.2 ml of glutamate (1 mol/L) or isotonic saline (control) were injected into the anterior portion of the temporalis muscle. Palpation of the masseter muscle was done using four different forces (0.5 kg, 1 kg, 2 kg and 4 kg). Participants rated the perceived intensity of the palpation and any referred sensations on a 0–50–100 numeric rating scale, the perceived pain intensity following the injections on an electronic visual analogue scale and drew any referred sensations they experienced. No difference in referred sensations location, area and frequency was shown r during palpation either before or after injections (P > 0.05). A moderate correlation was found between perceived sensation scores and referred sensations intensity for the temporalis muscle following glutamate injection (r = 0.407, P < 0.05). Moreover, significantly more participants reported referred sensations for glutamate injections into the temporalis muscle when compared to isotonic saline (P < 0.05). Finally, a significant decrease in the perceived intensity of palpation of the masseter muscle was seen after glutamate injection in the temporalis muscle (P < 0.05). In the current study, location, area and frequency of referred sensations following mechanical stimulation of the masseter muscle were not altered by the application of a painful stimulus to the temporalis muscle. In addition, there seems to be a positive relationship between painful stimuli and referred sensations frequency and intensity elicited from the temporalis muscle.

Research Thu, 01 Dec 2022 12:54:18 +0100 f5b80560-4739-4c80-a96e-da5d034935d8
<![CDATA[Orofacial manifestations of juvenile idiopathic arthritis from diagnosis to adult care transition:]]> Glerup, M., Tagkli, A. ., Küseler, A., et al. Research Thu, 01 Sep 2022 12:54:18 +0200 18c9ac8f-32cf-4861-aaa2-6f13a02b099a <![CDATA[Comparative assessment of factors causing image quality degradation in CBCT: how far are we from a ‘perfect’ scan?]]> Pauwels, R. J. C., Spin-Neto, R., Wenzel, A. Research Sat, 01 Jan 2022 12:54:18 +0100 8931fed3-e703-45e8-b14a-63499cfa2ccf <![CDATA[Magnetic resonance imaging in the diagnosis of periapical and periodontal disease: systematic review]]> Johannsen, K. M., Fuglsig, J. M. D. C. E. S., Hansen, B., Matzen, L. H., Spin-Neto, R. Research Sat, 01 Jan 2022 12:54:18 +0100 e6d1adf9-afc0-4db7-9307-4026a99c15f3 <![CDATA[Alveolar bone measurements in magnetic resonance imaging compared with cone beam computed tomography: ex vivo study]]> Fuglsig, J. M. D. C. E. S., Hansen, B., Schropp, L., Nixdorf, D. R., Wenzel, A., Spin-Neto, R. Research Sat, 01 Jan 2022 12:54:18 +0100 f92b9d83-4723-470f-9e52-82f9effa7ed5 <![CDATA[Diagnostic accuracy of magnetic resonance imaging and cone beam computed tomography for apical periodontitis assessment: ex vivo study]]> Spin-Neto, R., Kruse, C., Kirkevang, L., et al. Research Sat, 01 Jan 2022 12:54:18 +0100 f7b0378f-7f68-4b3f-bde2-00979010e691 <![CDATA[Cultural and Traditional Oral Practices:]]> Kemoli, A., Johansson, A., Lindholm, M., et al. Research Sat, 01 Oct 2022 12:54:19 +0200 cd99fee9-83c5-4fb3-bdb3-383a32ce0b74 <![CDATA[Other common non-neuropathic facial pain conditions]]> Taneja, P., Baad-Hansen, L. Education Mon, 03 Oct 2022 12:54:19 +0200 4de1dfe8-3a03-466e-8606-d9028d7bc060 <![CDATA[Image quality assessment of three cone beam computed tomography scanners-an analysis of the visibility of anatomical landmarks]]> Baumann, E., Bornstein, M. M., Dalstra, M., Verna, C., Dagassan-Berndt, D. C. BACKGROUND/OBJECTIVES: The aim of this study was to evaluate large field of view (FoV) subjective image quality of three cone-beam computed tomography (CBCT) machines to assess the threshold for reliable diagnostic perceptibility when lowering exposure settings.

MATERIALS AND METHODS: One entire cadaver's head was scanned using three CBCT scanners. The largest available FoV of each device, imaging orthodontic relevant structures, was applied. CBCT datasets with different image quality based on standard to minimum scanning parameters were acquired. Five dentists evaluated the visibility of selected anatomical structures of the upper and lower jaw using a 5-point rating scale.

RESULTS: Image quality depends on parameters such as a minimum voxel size of 0.2 to 0.4mm or a minimum of 4mA. A reduction in number of images (scanning protocol) reduces image quality. Visualization of different anatomical structures for orthodontic treatment planning requires distinct scanning protocols to support adequate perception of these structures.

LIMITATIONS: This study does not account for the evaluation of paediatric anatomical structures due to the availability of cadaver's head.

CONCLUSIONS: CBCT scans performed for orthodontic purposes using a large FoV with reduced parameters (400 µm, 2 to 4 mA and low dose protocols) are acceptable for visualization of large anatomical structures. Further lowering these parameters will not be sufficient to view small anatomical structures. Orthodontic indications will have to define specific anatomical structures to choose adequate scanning protocols to reduce dose and ensure reliable diagnostic visibility.

Research Sat, 01 Oct 2022 12:54:19 +0200 261b53bb-0fce-476a-a4ba-40fb33eec615
<![CDATA[Tandregulering med alignere]]> Kristensen, K. D., Henrikson, T. . effektiviteten af alignere til specifikke tandflytninger samt illustrere effekten med to patienttilfælde. Artiklen er tænkt som en overordnet introduktion
til den nuværende evidens omkring behandling med alignere, hvorefter den interesserede kliniker kan fordybe sig yderligere efterfølgende.]]>
Research Tue, 01 Mar 2022 12:54:19 +0100 dfc4c552-5451-4eb8-84ce-13889aca27a0
<![CDATA[Stability of mandibular implants with Morse taper and external hexagon connections placed under immediate loading]]> Paganelli, O. E. B., Santos, P. L., Spin-Neto, R., Pereira-Filho, V. A., Margonar, R. The aim of this study was to compare the longitudinal stability of implants with Morse taper and external hexagon connections placed in the anterior mandible and subjected to immediate functional loading. Nine patients each received 4 mandibular implants placed between the mental foramina. In each patient, 2 implants on the left side of the arch had Morse taper prosthetic connections, and 2 implants on the right side had external hexagon prosthetic connections. Mandibular overdentures and opposing removable complete dentures were placed within 72 hours after implant surgery. Clinical evaluation of the implants via magnetic transduction resonance frequency analysis was performed immediately following surgery and 3 months, 6 months, and 2 years following surgery to obtain the implant stability quotient (ISQ). The data obtained were parametric according to the Kolmogorov-Smirnov normality test. The lowest ISQ of any implant was approximately 67, representing reliable osseointegration. The only statistically significant difference between the 2 types of prosthetic connection was found in the initial period (immediately following surgery), when the external hexagon connection in the distal position presented greater stability than did the Morse taper connection in the same position on the opposite side (P < 0.05; Student t test). In intragroup comparisons, no statistically significant differences were found regarding the positions of the implants in the mandible. When the different follow-up periods were evaluated, there were statistically significant differences only in the external hexagon group, with significant reductions in stability of both mesial and distal implants at 6 months compared to other time periods (P < 0.05; Tukey test). Within the limitations of the study, it can be concluded that both Morse taper and external hexagon prosthetic connections provide good stability in an immediate functional loading protocol.

Research Tue, 01 Mar 2022 12:54:19 +0100 9717c2e8-36a8-4012-9e8c-4ec851a9694e
<![CDATA[Effect of different thresholds on the accuracy of linear and volumetric analysis of native-and grafted-bone]]> Lima, J. R., Bernardino, S. S., Pereira, L. D. S. G., et al. The study aimed to evaluate the accuracy of Micro-CT in linear and volumetric measurements in native (NB) and grafted bone (GB) areas. A total of 111 biopsies of maxillary sinuses grafted with deproteinized bovine bone (DBB) in humans were evaluated. The linear measurements were performed to measure the length of the NB and GB. Furthermore, the amount of mineralized tissues at the NB and GB was performed. In the histomorphometry analysis the percentage of mineralized tissues at the NB and GB was obtained in two histological sections while the mineralized tissues were measure in the micro-CT varying the thresholds of the grayscale varying from 90-250 to 90-150 with 10 levels of variation between each one was applied. Then these data were correlated in order to check the higher r level between the histomorphometry and micro-CT thresholds intervals. The linear length of the NB was 2.44±0.91mm and 2.48±1.50mm, respectively, for micro-CT and histomorphometry (r =0.57), while the linear length of the GB was 3.63±1.66mm and 3.13±1.45mm, respectively, for micro-CT and histomorphometry (r =0.74) Histomorphometry showed 45.91±11.69% of bone in NB, and 49.57±5.59% of bone and biomaterial in the GB. The total volume of mineralized tissues that were closest to the histometric analysis were 43.75±15.39% in the NB (Threshold:90-240; r = 0.50) and 51.68±8.42% in the GB (Threshold:90-180; r =-0.028). The micro-CT analysis showed good accuracy in the linear analysis in both portions of the biopsies but for volumetric analysis just in NB.

Research Fri, 01 Jul 2022 12:54:19 +0200 95f79d37-c2ae-4580-ac3b-430b7730d73c
<![CDATA[Ny type af glasfiberforstærkede rodstifter har ikke signifikant større brudstyrke]]> Ranjkesh, B., Haddadi, Y., Krogsgaard, C. A., Schurmann, A. ., Bahrami, G. Communication Tue, 01 Nov 2022 12:54:19 +0100 30c9041a-e018-4b76-9ff3-13a97182bfe0 <![CDATA[Long-term Safety of Treatment with Autologous Mesenchymal Stem Cells in Patients with Radiation-Induced Xerostomia]]> Lynggaard, C. D., Grønhøj, C., Jensen, S. B., et al. Purpose: Mesenchymal stem/stromal cell therapy may reduce radiation-induced xerostomia. We investigated the long-term safety of autologous adipose tissue-derived mesenchymal stem/stromal cell (ASC) injections into the submandibular glands. Experimental Design: An investigator-initiated, randomized, single-center, placebo-controlled trial. Previous patients with oropharyngeal squamous cell carcinoma with radiation-induced xerostomia were randomly (1:1) allocated to receive a 2.8 million ASCs/cm3 injection or placebo in both submandibular glands and followed for a minimum of 2 years. The primary endpoint was number of serious adverse events (SAE). Secondary endpoints included whole saliva flow rates and xerostomia-related symptoms. Data analysis was based on the intention-to-treat population using repeated measures mixed-effects linear models. Results: Thirty-three patients were randomized; 30 patients were treated (ASC group, n = 15; placebo group, n = 15). Longterm safety data were collected from all 30 patients. During follow-up, 6 of 15 (40%) of the ASC-treated patients versus 5 of 15 (33%) of the placebo patients experienced an SAE; no SAEs appeared to be treatment related. Unstimulated whole saliva flow rate increased to 0.20 and 0.16 mL/minute in the ASC and placebo group, respectively, yielding a 0.05 mL/minute (95% confidence interval: 0.00-0.10; P = 0.051) difference between groups. Patient-reported xerostomia symptoms diminished according to a decreased xerostomia questionnaire summary score of 35.0 and 45.1, respectively [-10.1 (-18.1 to -2.2); P = 0.013]. Three of the visual analog scale xerostomia measures indicated clinical benefit following use of ASC. Conclusions:Our data show that ASC therapy is safe with a clinically relevant effect on xerostomia-related symptoms. Confirmation in larger randomized controlled trials is warranted.

Research Fri, 01 Jul 2022 12:54:19 +0200 210a405f-c255-42f2-bbd8-50a6a83bb727
<![CDATA[Tandlægens transition]]> Musaeus, P., Lindelof, D., Kirkevang, L. nyuddannet kræver en højere grad af selvstændighed og produktion, mens den tandlægestuderende modtager løbende supervision og feedback
på opgaver og behandlinger på tandlægeskolen.
I denne artikel gennemgår vi forskning i læringsfaktorer, der har betydning for, hvordan tandlæger
kan få en vellykket overgang til praksis. Der trækkes på læringsforskning, dernæst på sundheds- og
organisationsforskning. Specifikt fokuserer vi på,
hvordan tandlægen kan opleve en positiv overgang
til sit første job. Og vi belyser betydningen af arbejdspladslæring herunder støtte til læringskultur,
feedback, kollegial vejledning og målrettet træning.
Med afsæt i forskning diskuteres mulige indsatser
til udvikling af et formaliseret uddannelsesforløb
for nyuddannede tandlæger. ]]>
Research Sat, 01 Oct 2022 12:54:19 +0200 edfdeb16-29e1-4d1f-9e39-79232b8cdd00
<![CDATA[Survey on retention procedures and use of thermoplastic retainers among orthodontists in Norway, Sweden, and Denmark]]> Hamran, T., Čirgić, E., Aiyar, A., Vandevska-Radunovic, V. Background: Orthodontic retention is the most important factor after successful orthodontic treatment. The use of thermoplastic retainers has increased in recent years, but information is lacking about the product materials and orthodontists’ awareness of the products they use. The aim of this survey was to map the retention protocols among Scandinavian orthodontists, particularly their use of thermoplastic retainers. Furthermore, the aim was to investigate their knowledge of thermoplastic materials and record any possible adverse effects. Methods: An online questionnaire was prepared, and 667 orthodontists in Norway, Sweden, and Denmark were invited to take the survey. The survey was sent to all members of the national orthodontic associations using Nettskjema in Norway and Microsoft Forms in Sweden and Denmark. Data were collected anonymously and analyzed using chi-square and correlation coefficients. Results: Of the 667 orthodontists, 432 (64%) responded (59% female). The most common retention protocol (51%) was fixed retainer in both maxilla and mandible and thermoplastic retainer in the maxilla. Two-thirds of the orthodontists were unaware of the thermoplastic material used, and 58% did not acquire knowledge of the materials. Only 1% of the respondents had registered adverse reactions to thermoplastic retainers, and none were aware of the type of material that was used. Conclusions: Scandinavian orthodontists use similar retention protocols, with the most common being fixed retainer in the mandible and dual retention, fixed, and thermoplastic retainer in the maxilla. Orthodontists’ knowledge about thermoplastic materials was insufficient, but adverse effects related to thermoplastic retainer use were rare.

Research Mon, 01 Aug 2022 12:54:19 +0200 7fa80010-2e02-437b-8221-c99f6706f701
<![CDATA[Effect of standardized training in combination with masseter sensitization on corticomotor excitability in bruxer and control individuals]]> Boscato, N., Exposto, F. G., Costa, Y. M., Svensson, P. Recently, it has been proposed that bruxism could represent an overlearned behavior due to the absence of corticomotor plasticity following a relevant tooth-clenching task (TCT). This study assessed the modulatory effects of a nerve growth factor (NGF) injection on masseter muscle corticomotor excitability, jaw motor performance, pain, and limitation in bruxer and control participants following a TCT. Participants characterized as definitive bruxers or controls were randomly assigned to have injected into the right masseter muscle either NGF or isotonic saline (IS), resulting in a study with 4 arms: IS_Control (n = 7), IS_Bruxer (n = 7); NGF_Control (n = 6), and NGF_Bruxer (n = 8). The primary outcome was the masseter motor evoked potential (MEP) amplitude measured at baseline and after a TCT. After the interventions, significantly higher and lower MEP amplitude and corticomotor map area were observed, respectively, in the IS_Control and NGF_Control groups (P < 0.05). Precision and accuracy depended on the series and target force level with significant between-group differences (P < 0.01). NGF-induced masseter muscle sensitization, in combination with a training-induced effect, can significantly impact the corticomotor excitability of the masseter muscle in control participants indicating substantial changes in corticomotor excitability, which are not observed in bruxers. These preliminary findings may have therapeuthic implications for the potential to "detrain" and manage bruxism, but further studies with larger sample sizes will be needed to test this new concept.

Research Sat, 01 Oct 2022 12:54:19 +0200 31d40348-2bac-4bf7-8052-7e67ae312221
<![CDATA[Obstructive sleep apnoea in pycnodysostosis]]> Ferlias, N., Gjørup, H., Doherty, M. A., Haagerup, A., Pedersen, T. K. Aim: To assess the upper airway (UA) morphology in patients with pycnodysostosis with a 3D analysis, compare results with normative data and investigate the correlation of the total volume (TV) with other UA morphology variables. Materials and methods: Cone beam computed tomography (CBCT) images of eight Danish patients with pycnodysostosis (4 males and 4 females with a mean age of 31.8 years, SD: 16.3 years) were analyzed using Mimics® (Materialise®) and compared with a sex- and age-matched control group (6 males and 8 females with a mean age of 33.6 years, SD: 18.6 years). Results: The distance from the tip of the epiglottis (E) to the Frankfurt horizontal plane (Fp) was significantly shorter in the pycnodysostosis group (P <.042). Regarding the cross-sectional measurements, at the ‘maximum constriction’ (P <.005), the ‘upper airway limit’ (P <.001) and the ‘lower airway limit’ (P <.035) cross-sections were significantly smaller in the pycnodysostosis group. The volumes ‘nasopharynx’ (P <.002) and ‘total airway’ (TV) (P <.01) were also significantly smaller. Conclusion: Patients with pycnodysostosis have a reduced total airway as well as nasopharyngeal volume compared with matched controls. Additionally, they have a reduced cross-sectional area in the upper and lower borders of the UA, and the area of maximum constriction is also reduced. These factors might explain the high prevalence of obstructive sleep apnoea in pycnodysostosis. Total airway is positively correlated with total length and cross-sections at all levels including the maximum constriction area as well as the anteroposterior dimension at the upper and lower airway borders.

Research Tue, 01 Nov 2022 12:54:19 +0100 78281aae-e312-41f1-a181-b3f9959d88a4
<![CDATA[Outcomes reporting in systematic reviews on non-surgical root canal treatment]]> Kirkevang, L. L., El Karim, I. A., Duncan, H. F., Nagendrababu, V., Kruse, C. Background: Studies related to non-surgical root canal treatment are amongst the most frequently performed clinical studies in endodontics. However, heterogeneity in reporting outcomes and lack of standardization is a significant challenge to evidence synthesis and guideline development. Objectives: The aims of the present scoping review were to (a) identify outcomes reported in systematic reviews evaluating non-surgical root canal treatment; (b) identify how and when the reported outcomes were measured; (c) assess possible selective reporting bias in the included studies. The information obtained in this study should inform the development of a core outcome set (COS) for non-surgical root canal treatment. Methodology: Structured literature searches were performed to identify systematic reviews on non-surgical root canal treatments published in English between January 1990 and December 2020. Two reviewers undertook study selection and data extraction. Outcomes were categorized according to a healthcare taxonomy into five core areas (survival, clinical/physiological changes, life impact, resource use, and adverse events). The outcome measurement tools and length of follow-up were recorded. Results: Seventy-five systematic reviews were included, of which 40 included meta-analyses. Most reviews reported on physiological and clinical outcomes, primarily pain and/or radiographic assessment of periapical status, and a variety of measurement tools and scales were used. Few reviews focused on tooth survival, life impact, resources, and adverse events. The heterogeneity amongst the reviews was large on all parameters. Less than 40% of the reviews assessed the risk of selective reporting. Discussion: Overall aims of the included reviews were highly heterogenic; thus, outcomes and how they were measured also varied considerably. Patient-centred outcomes and the use of resources were rarely reported on. Conclusions: Most studies reported on physiological and clinical outcomes, in particular pain and/or radiographic healing. Measurement tools, scales, thresholds, and follow-up periods varied greatly within each outcome, making comparison across studies complicated. Less than 40% of the reviews assessed risk of selective reporting; thus, selective bias could not be ruled out. The presented information on reported outcomes, measurement tools and scales, and length of follow-up may guide the planning of future research and inform the development of a COS for non-surgical root canal treatment.

Research Tue, 01 Nov 2022 12:54:19 +0100 0e727530-61c7-4d9e-8f8a-cac9dc4fc0e7
<![CDATA[Force Systems Produced by Different Cantilever Configurations during Deactivation]]> Bilinska, M., Golliez, I. M., Dalstra, M. Intrusion with a three-piece arch is routinely achieved during orthodontic treatment. This study aimed to experimentally determine how the cantilever design influences the generated force system. Both straight and arch-formed cantilever designs: tip-back (TB), flat curve (FC) deep curve (DC), and 3 mm and 6 mm high utility arch (UA3; UA6) were activated for 5 mm and 10 mm. Force systems were determined by a hexapod. Typodonts simulating a three piece-intrusion arch were scanned using an intraoral scanner (3Shape, TRIOS, Denmark) before (T0) and after (T1) the experiment and superimposed with Mimics software (Materialise, Leuven, Belgium). Data were analyzed. All straight designs displayed an extrusive force in the vertical plane, and all arch-formed an intrusive force. DC and TB showed a retrusive force in the sagittal plane and UA6 a protrusive. For the medial/lateral forces, DC and TB displayed a medial, and UA6 a lateral force. Configurations can be distinctively ranked from DC, FC, TB to UA3, and UA6 according to the increasing protrusive nature of the generated sagittal forces. A DC or TB configuration should be used for intrusion and retraction, while for an intrusion and a protrusion, a UA6 configuration. All straight configurations showed a higher force level than the arch-formed configurations.

Research Fri, 01 Jul 2022 12:54:19 +0200 26704519-a5a1-425a-9a86-6463a9886e9d
<![CDATA[The Effect of Ligature Type on Lateral Tooth Movement during Orthodontic Treatment with Lingual Appliances—An In Vitro Study]]> Reichardt, E., Decker, S., Dalstra, M., et al. (1) Background: One of the most challenging parts in lingual orthodontics is the control and correction of the tip of anterior teeth, due to the occlusal open vertical slot of the incisors in lingual systems. The presented experimental in-vitro study was performed to determine the maximal tipping moment of the anterior teeth between two types of lingual brackets, the Incognito™ Appliance System (Incognito, TOP-Service, Bad Essen, Germany) and Tip-Bar™ system (Incognito, TOP-Service, Bad Essen, Germany). Furthermore, twelve different ligation methods and two different ligature materials were investigated. (2) Methods: The measurement was performed by assessing the stiffness and ultimate strength of the ligature in a uniaxial material testing machine (Instron, Norwood, MA, USA) using a 0.025 × 0.018 inch stainless steel wire. (3) The results showed that the highest precision for control tipping of anterior teeth was determined for the 0.010 inch Stainless Steel Tie (Pelz and Partner). Furthermore, the Tip-Bar™ brackets increased the maximal moment by 33.8% for elastic and steel ligatures. (4) Conclusions: The lateral tooth movement is highly dependent on the type of ligature and applied material during orthodontic treatment with lingual appliances. The use of 0.010 inch steel ligatures and the Tip-Bar™ bracket design results in better alignment in the anterior teeth segment.

Research Sun, 01 May 2022 12:54:19 +0200 13f44534-b682-453f-9ddd-6e3247a3ace9
<![CDATA[Hypnosis on acute dental and maxillofacial pain relief]]> Merz, A. E., Campus, G., Abrahamsen, R., Wolf, T. G. Introduction/objectives: The effects of hypnosis on acute pain have been discussed recently, resulting in increased attention in the dental/maxillofacial field offering new perspectives, especially in emergency situations, trauma, or acute inflammatory situations where conventional pharmaceuticals are contraindicated due to allergies or intolerance reactions. Data: To systematically evaluate and assess the effects of hypnosis on acute dental/facial pain relief. Randomized controlled trials, cohort studies, controlled clinical trials, cross-sectional studies, evaluation, and validation studies, following the PRISMA guidelines, of human subjects of all ages were included. Sources: Five electronic databases (Cochrane, Embase, MEDLINE via PubMed, LILACS, Scopus) were screened for studies published between 1989 – 2021. A NIH quality-assessment-tool was performed. Study selection/results: 27 papers have been included and a meta-analysis was performed. Hypnosis has been reported to reduce intraoperative and postoperative pain as well as the use of analgesics in various dental procedures such as tooth extraction. Highly hypnotizable subjects generally respond better to hypnosis. Different hypnosis techniques were used for pain relief and relaxation. The studies show a large heterogeneity. Conclusion: Although there are only a small number of studies on the subject so far, evidence can be confirmed for the effects of hypnosis on acute pain relief in dental/maxillofacial area. Despite the promising results, further research is needed. Clinical significance: Hypnosis offers a possible alternative to conventional pain medications for acute dental and maxillofacial pain, especially in cases of allergies or contraindications; it can be easily applied by a trained practitioner.

Research Mon, 01 Aug 2022 12:54:19 +0200 3d22a247-4589-4a21-9993-132506a1d106
<![CDATA[Prevention of Initial Bacterial Attachment by Osteopontin and Other Bioactive Milk Proteins]]> Kristensen, M. F., Sorensen, E. S., Del Rey, Y. C., Schlafer, S. A considerable body of work has studied the involvement of osteopontin (OPN) in human physiology and pathology, but comparably little is known about the interaction of OPN with prokaryotic cells. Recently, bovine milk OPN has been proposed as a therapeutic agent to prevent the build-up of dental biofilms, which are responsible for the development of caries lesions. Bioactive milk proteins are among the most exciting resources for caries control, as they hamper bacterial attachment to teeth without affecting microbial homeostasis in the mouth. The present work investigated the ability of OPN to prevent the adhesion of three dental biofilm-forming bacteria to saliva-coated surfaces under shear-controlled flow conditions in comparison with the major milk proteins alpha-lactalbumin, beta-lactoglobulin, alpha s1-casein, beta-casein and kappa-casein, as well as crude milk protein. OPN was the most effective single protein to reduce the adhesion of Actinomyces naeslundii, Lactobacillus paracasei subsp. paracasei and Streptococcus mitis. beta-casein and crude milk protein also had a pronounced effect on all three species, which suggests binding to different microbial surface structures rather than the blocking of a specific bacterial adhesin. Bioactive milk proteins show potential to delay harmful biofilm formation on teeth and hence the onset of biofilm-related oral disease.

Research Mon, 01 Aug 2022 12:54:19 +0200 fc6a9049-5151-4606-adfd-dabff657ffb9
<![CDATA[Fluorescence lectin binding analysis of carbohydrate components in dental biofilms grown in situ in the presence or absence of sucrose]]> Dige, I., Paque, P. N., Del Rey, Y. C., Lund, M. B., Schramm, A., Schlafer, S. Carbohydrate components, such as glycoconjugates and polysaccharides, are constituents of the dental biofilm matrix that play an important role in biofilm stability and virulence. Exopolysaccharides in Streptococcus mutans biofilms have been characterized extensively, but comparably little is known about the matrix carbohydrates in complex, in situ-grown dental biofilms. The present study employed fluorescence lectin binding analysis (FLBA) to investigate the abundance and spatial distribution of glycoconjugates/polysaccharides in biofilms (n = 306) from 10 participants, grown in situ with (SUC) and without (H2O) exposure to sucrose. Biofilms were stained with 10 fluorescently labeled lectins with different carbohydrate specificities (AAL, ABA, ASA, HPA, LEA, MNA-G, MPA, PSA, VGA and WGA) and analyzed by confocal microscopy and digital image analysis. Microbial composition was determined by 16S rRNA gene sequencing. With the exception of ABA, all lectins targeted considerable matrix biovolumes, ranging from 19.3% to 194.0% of the microbial biovolume in the biofilms, which illustrates a remarkable variety of carbohydrate compounds in in situ-grown dental biofilms. MNA-G, AAL, and ASA, specific for galactose, fucose, and mannose, respectively, stained the largest biovolumes. AAL and ASA biovolumes were increased in SUC biofilms, but the difference was not significant due to considerable biological variation. SUC biofilms were enriched in streptococci and showed reduced abundances of Neisseria and Haemophilus spp., but no significant correlations between lectin-stained biovolumes and bacterial abundance were observed. In conclusion, FLBA demonstrates the presence of a voluminous biofilm matrix comprising a variety of different carbohydrate components in complex, in situ-grown dental biofilms.

Research Sat, 01 Oct 2022 12:54:19 +0200 e69d3814-ada7-4755-84e5-2a53bc7fc77f
<![CDATA[The Highly Leukotoxic JP2 Genotype of <i>Aggregatibacter actinomycetemcomitans</i> Is Present in the Population of the West African Island, Sal in Cape Verde]]> De Soet, J. J., Claesson, R., Haubek, D., Johansson, A., Buijs, M. J., Volgenant, C. M.C. Aggregatibacter actinomycetemcomitans is strongly associated with severe periodontitis, possibly due to its production of a potent leukotoxin. A genetic variant, the JP2 genotype, was found to produce more leukotoxin than the wild type because of a mutation in the leukotoxin gene, and this genotype is frequently found in African populations. The aim of this study was to investigate whether this JP2 genotype can be found in a randomly selected group of inhabitants of Sal, Cape Verde. Twenty-nine adults between 20 and 59 years of age (58.6% female) participated, and information on their oral health and living standards was collected. An oral examination was performed for each participant, including DMF-T and CPI scores. Plaque and saliva samples were collected and transported to Europe, where DNA was isolated, and the concentration of A. actinomycetemcomitans and its JP2 genotype was determined using dedicated PCR analyses. All 29 plaque and 31% of the saliva samples harboured A. actinomycetemcomitans, and two participants were positive for the JP2 genotype. The presence of this JP2 genotype was not associated with either CPI or DMF-T. This pilot study is the first to describe the presence of the A. actinomycetemcomitans JP2 genotype in a Cape Verdean population living in the Cape Verde Islands, and the findings warrant further research.

Research Sun, 01 May 2022 12:54:19 +0200 1212f2bc-2028-48c3-b55c-fe3f1aa6d146
<![CDATA[Cantilevers]]> Bilinska, M., Kristensen, K. D., Dalstra, M. This review aims to discuss and illustrate various uses of cantilevers to solve multiple clinical issues and prove their versatility. Cantilevers are commonly used in the segmented arch technique, and they can be designed to solve various clinical problems with highly predictable results. Its design and shape can modify the various combinations of vertical and horizontal forces. The novel trend is to combine cantilevers with skeletal anchorage. Cantilevers offer a very simple and statically determined force system. The advantage is the control over side effects, which normally occur on the anchor teeth and the occlusion. The disadvantages include possible side effects on the anchorage unit, when the anchorage is poorly controlled. The review highlights the clear benefits of cantilever use in complex corrections of single teeth, segments, and entire arch with a diminished effect on the dentition, also with the use of skeletal anchorage. With their simple and easily tailored design, these springs can be called an orthodontic multi-tool.

Research Fri, 01 Jul 2022 12:54:19 +0200 1b593473-cbe0-4a76-b8c1-f529857f3225
<![CDATA[Corticomotor plasticity effect of a mandibular advancement device in patients with obstructive sleep apnea.]]> Castrillon, E. E., Costa, Y., Hayakawa, H., et al. Materials and Methods: Twenty-eight mild or moderate OSA adult patients without the presence of chronic orofacial pain or headache or uncontrolled systemic conditions participated in this randomized placebo-controlled crossover study. The participants used a MAD at 40% of a maximal protrusion (MAD active) followed by two weeks of a MAD without any jaw protrusion (MAD placebo) or vice-versa during sleep. There was a wash-out period of two weeks between the two positions. Assessments were made at baseline, after MAD active, and after MAD placebo. Transcranial magnetic stimulation (TMS) assessed the amplitude of motor evoked potential (MEP) on the right masseter, tongue, and first dorsal interosseous (FDI). Repeated-measures ANOVA assessed differences in MEPs for each site. Moreover, differences in the map MEP volume were evaluated. Multiple comparison analyses were performed using Tukey's Honestly Statistical Difference.
Results: There were no significant MEP amplitude changes for the hand (p = 0.129). However, the MAD position was significantly affected for both masseter and tongue (p < 0.001) corticomotor excitability. There was an increase in the MEP amplitude following the MAD active when compared to baseline and MAD placebo position (p < 0.001). In contrast, there were no differences between baseline and placebo positions (p > 0.050). Finally, the MAD position (p < 0.001) had a significant main effect on the map volume. There was an increase in the MEP amplitude following the MAD active position compared to the baseline and MAD placebo position. The FDI presented the biggest map volume (p < 0.003).
Conclusion: MAD can induce neuroplastic changes in the corticomotor pathways in mild to moderate OSA patients, indicating potential central mechanisms. These findings can contribute to further understanding of the mechanisms of action of oral appliances to treat OSA.]]>
Research Thu, 01 Sep 2022 12:54:19 +0200 11e37f81-d5e8-48b1-81d8-5f7cea65c00c
<![CDATA[Ortodontisk behandling på voksne]]> Laursen, M. G. Research Mon, 01 Aug 2022 12:54:19 +0200 84f6ee77-2cbc-481d-a1c7-9e48d211de0f <![CDATA[Behandling af trangstilling]]> Laursen, M. G., Botticelli, S. the adult patient to seek orthodontic treatment. Crowding
is a frequent reason for patients not being confident with
their smile. Three main strategies are available to gain space
in the dental arch: 1) expansion, 2) interproximal reduction
and 3) extraction. Not only the severity of crowding determines
the treatment approach, as the intervention aims at
harmonious facial aesthetics, normal oro-facial function,
and periodontal health. The clinician bases the individualized
treatment plan on full orthodontic records. Space conditions
are assessed especially in relation to bucco-lingual
inclination of the teeth, facial physiognomy, occlusion, lip
and tongue function, and periodontal biotype. Expansion,
extraction, or interproximal reduction are complementary
strategies and can be combined according to individual
needs. Various fixed and removable types of appliances have
different properties. The appliance design depends on the
treatment goal and the planned tooth movements.]]>
Communication Mon, 01 Aug 2022 12:54:19 +0200 22f96a6b-f360-4719-a52b-19d0d60a4e66
<![CDATA[Editorial]]> Salmi, M., Wolff, J., Mäkitie, A. Research Sat, 01 Jan 2022 12:54:19 +0100 73374d68-9856-4f60-8754-a67600280109 <![CDATA[Peripheral N-methyl-D-aspartate receptor activation contributes to monosodium glutamate-induced headache but not nausea behaviours in rats]]> Benbow, T., Teja, F., Sheikhi, A., Exposto, F. G., Svensson, P., Cairns, B. E. Monosodium glutamate induces behaviors thought to reflect headache and nausea in rats. We explored the effects of the N-methyl-D-aspartate receptor antagonist (2R)-amino-5-phosphonovaleric acid, the inotropic glutamate receptor antagonist kynurenic acid, and the CGRP receptor antagonist olcegepant, on monosodium glutamate-induced increases in nocifensive, headache-like and nausea behaviours. Effects of these antagonists on motor function were examined with a rotarod. The effect of the dopamine receptor antagonist metoclopramide and the serotonin 3 receptor antagonist ondansetron on nausea behaviour was also assessed. (2R)-amino-5-phosphonovaleric acid, and to a lesser extent, kynurenic acid and olcegepant, reduced nocifensive and headache-like behaviours evoked by monosodium glutamate. No alteration in motor function by (2R)-amino-5-phosphonovaleric acid, kynurenic acid or olcegepant was observed. No sex-related differences in the effectiveness of these agents were identified. Nausea behaviour was significantly more pronounced in male than in female rats. Olcegepant, ondansetron and metoclopramide ameliorated this nausea behaviour in male rats. Ondansetron and metoclopramide also reduced headache-like behaviour in male rats. These findings suggest that peripheral N-methyl-D-aspartate receptor activation underlies monosodium glutamate-induced headache-like behaviour but does not mediate the nausea behaviour in rats.

Research Mon, 01 Aug 2022 12:54:19 +0200 e27c43be-50fc-4902-8064-649e9af7c07a
<![CDATA[Effect of osseodensification on the increase in ridge thickness and the prevention of buccal peri-implant defects]]> Frizzera, F., Spin-Neto, R., Padilha, V., et al. Background: Implant installation with conventional drilling can create buccal bone defects in areas of limited ridge thickness. Implant installation with osseodensification may aid in preventing buccal bone defects in these situations. This in vitro pilot study evaluated the impact of osseodensification on the increase in alveolar ridge thickness and the prevention of buccal peri-implant defects. Methods: Ten fresh pig mandibles with limited bone thickness were selected for use in an experimental randomized split mouth pilot study. Two site-preparation protocols were used: conventional drilling with cutting burs (CTL, n = 10) and osseodensification with Densah® burs (OD, n = 10). After implant bed preparation, 20 implants (4.5 × 10 mm) were placed in the prepared sites and the insertion torque was recorded. Clinical and photographic analysis evaluated ridge thickness and the extent (height, width, and area) of bone defects in the buccal and lingual bone walls following implant placement. Three-dimensional measurements were performed using STL files to analyze the increase in buccal ridge thickness following site preparation and implant placement. The height of the buccal bone defect was considered as the primary outcome of this study. Defect width, area, implant insertion torque, and linear buccal ridge increase after implant site preparation and installation were also assessed. Non-parametric evaluations were carried out with the Mann–Whitney test to verify intergroup differences. Results: There was no statistically significant difference between groups in the baseline ridge thickness. OD presented a significantly higher insertion torque, associated with reduced buccal and lingual bone defect width, in comparison to CTL. Conclusions: The increase in buccal ridge thickness after site preparation and implant placement was significantly higher in OD compared to CTL. Osseodensification increased the ridge thickness through expansion and reduced buccal bone defects after implant installation.

Research Sat, 01 Jan 2022 12:54:19 +0100 d77538df-bacc-4513-8a86-8338af33e04f