Publications - Publications

Forekomst af apikal parodontitis og rodbehandlinger i unge permanente tænder

Christensen, J. H., Vad, N. M. J., Kirkevang, L. — Mon, 01 Jan 2024 21:06:38 +0100

Hybrid Orthodontics for Aesthetic Deep Bite Correction—Case Series and General Clinical Considerations

Aiyar, A., Scuzzo, G. ., Scuzzo, G., Verna, C. — Sat, 30 Mar 2024 21:06:38 +0100

Acquired Dentofacial Deformity and Asymmetry

Stoustrup, P. B., Pedersen, T. K. — Thu, 01 Aug 2024 21:06:39 +0200

This chapter begins with a description of temporomandibular joint (TMJ) growth and development and its association with asymmetric dentofacial development. Dental occlusion is formed by a complex interplay of various morphological, physiological, genetic, and functional components. Dental asymmetries are often caused by an underlying skeletal mandibular asymmetry. Dentofacial deformity and skeletal asymmetries may lead to soft‐tissue asymmetries. In specific conditions, overgrowth may act as an underlying factor causing asymmetric development. Four general categories exist of acquired conditions leading to dentofacial deformity and asymmetry: autoimmune diseases and conditions, skeletal growth diseases, soft‐tissue conditions, and TMJ conditions. Understanding the pathophysiology of the underlying acquired condition is important to build an understanding of the etiology, diagnosis, and treatment. Distraction osteogenesis may be applied before skeletal maturity is reached as an early step in the total treatment sequence.

ASU effect on bone repair in defects grafted with bone substitute

Mon, 01 Jan 2024 21:06:39 +0100

Introduction: Grafted areas represent a region of lower biological quality than areas of native bone. Bioactive products can improve bone quality in grafted areas. Objective: To evaluate the effect of avocado/soybean unsaponifiables (ASU) on repair of critical-size calvarial defects (CSDs) filled with osteoconductive bone substitutes Material and method: One CCD (0.5 mm) was made in each of 84 rats. These defects were filled either with coagulum (COA), deproteinized bovine bone (DBB), or tricalcium phosphate/hydroxyapatite (TCP/HA). ASU (0.6 g/kg) or saline solution (CTR) was administered daily by gavage from 15 days before surgery until the animals were euthanized (15 or 60 days after surgery) totaling 7 animals per period/group. The composition of the tissues that filled the CSDs were analyzed by histomorphometric evaluation, while the amount of mineralized tissue was evaluated by micro–CT. Result: The bone filling in COA-ASU group was significantly higher than in the COA-CTR group (46.40 ±10.41% vs. 29.00 ± 8.81% at 15 days and 52.14 ± 6.12% vs. 42.71 ± 5.21% at 60 days) (p<0.05). There were no differences regarding the bone fill between the ASU and CTR groups in DBB and HA/TCP grafted CSDs. There were higher amount of mineralized tissues in the CSDs of the CTR groups than the ASU groups at 15 days (66.73 ± 6.70% vs. 52.25 ± 9.71% in DBB grafted CSDs and 53.16 ± 10.08% vs. 37.95 ± 4.70% in HA/TCP grafted CSDs) (p<0.05). Conclusion: ASU enhanced the bone repair in the CSDs filled with COA; however, this positive effect was not seen in DBB or HA/TCP grafted CSDs.

Non-radioactive strontium as a supplement to enhance osseointegration

Mon, 01 Jan 2024 21:06:39 +0100

Introduction: Due to its positive results on bone tissue, strontium also began to be used as an adjuvant in bone neoformation processes, mainly maxillofacial surgical procedures. Objective: To assess if the nonradioactive strontium (Sr) supplementation enhances the osseointegration of titanium implants in rats. Material and method: Seventy male rats (Rattus Norvegicus) were randomly divided into 5 groups, according to the systemic supplementation: Control-saline solution; SRAN50-strontium ranelate (SRAN) 50mg/kg/day; SRAN625-SRAN 625mg/kg/day; SCAR/SCHL30-strontium carbonate and strontium chloride (SCAR/SCHL) 30mg/kg/day; SCAR/SCHL365-SCAR/SCHL 365mg/kg/day. The drugs were administered via gavage, once a day, starting 15 days before surgery (1 titanium implant in each tibia), and persisted for 15 or 60 days. The right tibiae were used for biomechanical (removal torque) and immunohistochemical (Osteocalcin – OCN, and bone morphogenetic protein-BMP-2) evaluation. The left were used for microtomographic, and histomorphometric evaluation. Result: Increased removal torque for SRAN625 and SCAR/SCHL365 were observed when compared with the Control, in 15 days. However, no differences were found in the 60-days period among the groups. Microtomographic evaluation showed larger bone volume at 60 days, compared to 15 days, for all groups but SCAR/SCHL30. When all groups were compared, no differences were seen in the 15-days period, while in the 60-days SRAN625 and SCAR/SCHL365 were statistically higher than the Control. In the immunohistochemical analysis, higher doses (SRAN625 and SCAR/SCHL365) led to an increase of BMP-2 in 15 days. Histomorphometric analysis revealed no differences among the groups regarding bone-to-implant-contact and bone area around the implant threads. Conclusion: This study suggests that higher concentrations of systemic Sr lead to variably improved osseointegration-related parameters regarding the biomechanical and microtomographic evaluation.

The adjunctive use of systemic antibiotics in the non-surgical and surgical treatment of peri-implantitis

Okuma-Oliveira, B., Dos Reis, I. N. R., Souto, M. L. S., et al. — Tue, 19 Nov 2024 21:06:39 +0100

PURPOSE: To evaluate the additional benefits of the adjunctive use of systemic antibiotics in the non-surgical and surgical treatment of peri-implantitis. MATERIALS AND METHODS: A systematic search following the population, intervention, comparison, outcome and study design framework was conducted across the MEDLINE (via PubMed), Embase and Web of Science databases. The primary outcome was probing depth reduction, and the secondary outcomes were bleeding on probing, clinical attachment level, radiographic bone level changes, suppuration and clinical success. Data on outcome variables were pooled through random effects meta-analyses. RESULTS: Eight articles (seven studies) were included. For non-surgical interventions, systemic antibiotics reduced probing depth significantly after 1 year (n = 4; mean difference 1.33, 95% confidence interval 0.84 to 1.82; P 0.01), and also led to significant benefits in probing depth reduction at 3 and 6 months, clinical attachment level gain at 1 year (n = 3; mean difference 1.31, 95% confidence interval 0.68 to 1.95; P 0.01) and suppuration reduction at 3 months; however, no significant differences were found in bleeding on probing at 3 and 6 months, or clinical success at 1 year. For surgical treatment, antibiotics reduced probing depth significantly after 6 months, but no significant differences were noted after 1 year. Systemic antibiotics resulted in a significant increase in radiographic bone level after 1 year (n = 2; mean difference 0.96, 95% confidence interval 0.31 to 1.61; P 0.01) and a higher chance of clinical success (n = 2; odds ratio 2.16, 95% confidence interval 1.04 to 4.50; P = 0.009). In the combined analysis of non-surgical and surgical treatments for probing depth reduction at 1 year, systemic antibiotics showed a significant advantage (n = 5; mean difference 0.98, 95% confidence interval 0.56 to 1.40; P 0.01). Benefits extended to clinical attachment level gain, bone gain and increased likelihood of clinical success at 1 year. CONCLUSION: Non-surgical treatment of peri-implantitis with adjunctive systemic antibiotics led to significant benefits in probing depth reduction, clinical attachment level gain and suppuration reduction at 1 year. Surgical treatment with adjunctive systemic antibiotics showed significant benefits in terms of bone gain and clinical success at 1 year. Nevertheless, the variability in antibiotic protocols should be considered. The adjunctive use of systemic antibiotics should be evaluated with caution, as the benefits may not outweigh the risks of antibiotic resistance in less severe cases of peri-implantitis.

Maxillary rhinosinusitis of odontogenic origin

Pignaton, T. B., Spin-Neto, R., de Oliveira, G. J. P. L., Ferreira, C. E. d. A. — Mon, 01 Jan 2024 21:06:39 +0100

The present study presents a series of cases of maxillary rhinosinusitis related to dental infection and threated exclusively with the extraction of the compromised teeth. Eight patients were selected from a private practice dental institute presenting a violated Schneiderian membrane due to odontogenic infections, as confirmed by a Cone Beam computed tomography (CBCT) that was performed in all cases for diagnosis. The origin of these infection was due to endodontic of periodontal lesions, and the pulpar vitality tests and periodontal probing were executed in order to confirm that the source of the maxillary rhinosinusitis was due to the odontogenic infections. All the cases of maxillary rhinosinusitis were resolved after the tooth extraction, since the dental implants placement were indicated in all the cases. It is possible to conclude the importance of the diagnosis of infectious lesions of odontogenic origin for the differential diagnosis of rhinosinusitis to determine the treatment appropriated for the resolution of this illness.

Avaliação da perda óssea utilizando diferentes parâmetros na análise microtomográfica. Estudo em ratos

Sat, 01 Jan 2022 21:06:39 +0100

Introduction: the challenge in the use of Micro-Ct has been to establish and standardize adequate standards for scanning and image processing to obtain the maximum performance of the equipment and to allow the comparison of findings between different studies. Objective: this study aims to compare the percentage of bone volume in regions with periodontal bone loss using different methodologies to define the area to be analysed (ROI). Material and method: ten rats were submitted to periodontal disease induction, and, after euthanasia, the mandibles were scanned with slices of 9μ and 18μm thickness, with a rotation step of 0.3mm. The images were reconstructed using the NRecon software, and then, using the CTAnalyser-CTAn software, the areas of interest (ROI) around the second molars were defined. The first area of interest (ROI1) was defined in a rectangular pattern that was restricted to the interproximal and furcation regions, where the total area of bone tissue was obtained by adding the results of the 3 ROIs. The second area (ROI2) was defined in the coronal/apical direction around the second molar to its proximal limitations with the neighboring teeth, in which the percentage of bone tissue belonging to the roots was excluded from the evaluations. Analyses were performed with five different threshold values (130-50, 130-60, 130-70, 130-80, 130-90, and 130-100). Result: the analysis between the different ROIs showed that, in both analyses, there was a tendency towards a lower percentage of bone tissue the greater the grayscale contrast used. However, in the results obtained in ROI2, this difference was not statistically significant. Conclusion: with the results obtained, it can be concluded that the use of different thresholds for bone quantification, in areas where there was a periodontal disease, can bring divergent results; the definition of the area of interest interferes with the results obtained; and that obtaining an area of interest with the removal of the roots, proved to be less susceptible to the variation of the scanning parameters.

Surveying the landscape of diagnostic imaging in dentistry's future

Tyndall, D. A., Price, J. B., Gaalaas, L., Spin-Neto, R. — Wed, 01 May 2024 21:06:39 +0200

Background: Advances in digital radiography for both intraoral and panoramic imaging and cone-beam computed tomography have led the way to an increase in diagnostic capabilities for the dental care profession. In this article, the authors provide information on 4 emerging technologies with promise. Types of Studies Reviewed: The authors feature the following: artificial intelligence in the form of deep learning using convolutional neural networks, dental magnetic resonance imaging, stationary intraoral tomosynthesis, and second-generation cone-beam computed tomography sources based on carbon nanotube technology and multispectral imaging. The authors review and summarize articles featuring these technologies. Results: The history and background of these emerging technologies are previewed along with their development and potential impact on the practice of dental diagnostic imaging. The authors conclude that these emerging technologies have the potential to have a substantial influence on the practice of dentistry as these systems mature. The degree of influence most likely will vary, with artificial intelligence being the most influential of the 4. Conclusions and Practical Implications: The readers are informed about these emerging technologies and the potential effects on their practice going forward, giving them information on which to base decisions on adopting 1 or more of these technologies. The 4 technologies reviewed in this article have the potential to improve imaging diagnostics in dentistry thereby leading to better patient care and heightened professional satisfaction.

Dentale Magnetresonanztomographie

Al-Haj Husain, A., Valdec, S., Winklhofer, S., et al. — Sun, 01 Dec 2024 21:06:39 +0100

Dental magnetic resonance imaging (MRI) has long been perceived as overly complex, costly, and limited in availability. Despite the numerous advantages of this radiation-free, non-invasive procedure for soft tissue diagnostics in the head and neck region, its imaging capabilities for hard tissue, such as bones and teeth, have thus far remained limited in comparison to conventional X-ray technology. In recent years, however, technological advances have led to a notable enhancement in the image quality and the range of applications of dental MRI. This article presents a comprehensive review of the current literature on the utilization of dental MRI for dentomaxillofacial conditions. The article focusses on novel MRI protocols that have been specifically developed to address the inherent challenges associated with imaging the head and neck region. It also considers the latest technological advances, including innovative coils and the use of low and high-field MR systems. The practical case studies are from the fields of conservative dentistry, prosthodontics, orthodontics, oral surgery, and maxillofacial surgery, demonstrating the theoretical concepts and emphasizing the clinical advantages of dental MRI. In conclusion, dental MRI can be a valuable complement to and, in certain cases, a true alternative to X-ray-based procedures.

pH-FISH - coupled microscale analysis of microbial identity and acid–base metabolism in complex biofilm samples

Del Rey, Y. C., Kitzinger, K., Lund, M. B., et al. — Sun, 01 Dec 2024 21:06:39 +0100

Background: Correlative structural and chemical imaging of biofilms allows for the combined analysis of microbial identity and metabolism at the microscale. Here, we developed pH-FISH, a method that combines pH ratiometry with fluorescence in situ hybridization (FISH) in structurally intact biofilms for the coupled investigation of microbial acid metabolism and biofilm composition. Careful biofilm handling and modified sample preparation procedures for FISH allowed preservation of the three-dimensional biofilm structure throughout all processing and imaging steps. We then employed pH-FISH to investigate the relationship between local biofilm pH and the distribution of acid-producing (streptococci) and acid-consuming (Veillonella spp.) bacteria in dental biofilms from healthy subjects and caries-active patients. Results: The relative abundance of streptococci correlated with low biofilm pH at the field-of-view level, while the opposite trend was observed for Veillonella spp. These results suggest that clusters of streptococci contribute to the formation of acidic pockets inside dental biofilms, whereas Veillonella spp. may have a protective role against biofilm acidification. Conclusions: pH-FISH combines microscale mapping of biofilm pH in real time with structural imaging of the local microbial architecture, and is a powerful method to explore the interplay between biofilm composition and metabolism in complex biological systems.

Digital Workflows for Design and Fabrication of the Mandibular Anterior Repositioning Appliance

Vassis, S., Sefidroodi, M., Noeldeke, B., Özkan, V., Kristensen, K. D. — Tue, 01 Oct 2024 21:06:39 +0200

Guidelines for a surgery-first approach using Dolphin Imaging software and the Invisalign system

Sefidroodi, M., Shino, I. L., Vassis, S., et al. — Sat, 01 Jun 2024 21:06:39 +0200

Does the use of centring rings change the number of retakes or frequency and size of cone cuts in intraoral images performed by dental students?

Matzen, L. H., Schropp, L. — Mon, 01 Jan 2024 21:06:39 +0100

Scout images acquired prior to cone beam CT acquisitions

Christensen, J., Matzen, L. H., Hedegaard, M., Spin-Neto, R. — Fri, 01 Nov 2024 21:06:39 +0100

OBJECTIVES: The aim of the present study was to assess the reproducibility of findings in cone beam CT (CBCT) scout images. Furthermore, the study aimed to assess whether a scout image shows pathology not seen within the CBCT volume (ie, added diagnostic information) and therefore must be assessed on the same terms as the full volume. METHODS: Using a retrospective design, 233 CBCT reports and scout images were assessed. Kappa statistics and percentage of accordance were used to evaluate intra- and inter-observer reproducibility as well as agreement between scout and CBCT report. RESULTS: Intra- and inter-observer reproducibility was overall low (kappa ranging from -0.008 to 1.000). Agreement between findings reported in the CBCT and scout was also low. One hundred fourteen impacted teeth, one apical periodontitis, and two sinus conditions seen in the scout image were not registered in the full volume report due to the extended size of the scout image. CONCLUSIONS: Reproducibility of findings in scout images compared to CBCT volumes was low, and the scout showed very little additional diagnostic information. ADVANCES IN KNOWLEDGE: This study shows that although the reproducibility of viewing scout images is low, rare findings can go undetected if the scout is not assessed. Legislation regarding interpretation of scout images needs to be discussed.

Oral conditions are associated with salt taste disability among American adults

Fri, 01 Nov 2024 21:06:39 +0100

Aim: To explore the association between oral conditions and their interaction with salt taste disability among American adults. Methods: Data from the 2013–2014 NHANES cycle were used (n = 2373). The exposures were periodontitis, defined by the 2017 EFP-AAP classification, dental caries, missing teeth, and edentulism, as per the DMF-T index, and xerostomia. The outcome was salt taste disability, objectively assessed. Covariates included sex, age, educational level, poverty index, obesity, diabetes, smoking, alcohol consumption, and medications related to mouth dryness. Weighted multivariable logistic regression modeling was used to evaluate the relationship between oral conditions and their interaction and salt taste disability. Results: Participants who reported xerostomia were more likely to have salt taste disability (OR 2.42; 95%CI 1.44–4.07), especially those older than 60 years (OR 3.63; 95%CI 1.72–7.63). Among participants aged 40–59, xerostomia increased the chance of salt taste disability; however, the confidence interval included the null value. The interactions between xerostomia and edentulism increased the chance of salt taste disability. Conclusion: Oral conditions seem to influence the ability to taste salt. Dental professionals may help identify individuals with taste alterations and raise their awareness of the risk of systemic diseases that require the reduction of salt intake.

An Explainable and Conformal AI Model to Detect Temporomandibular Joint Involvement in Children Suffering from Juvenile Idiopathic Arthritis

Christensen, L. T. B., Straadt, D., Vassis, S., et al. — Thu, 02 May 2024 21:06:39 +0200

Large-Language Models in Orthodontics

Vassis, S., Powell, H., Petersen, E., et al. — Thu, 01 Aug 2024 21:06:39 +0200

BACKGROUND: Patients seeking orthodontic treatment may use large language models (LLMs) such as Chat-GPT for self-education, thereby impacting their decision-making process. This study assesses the reliability and validity of Chat-GPT prompts aimed at informing patients about orthodontic side effects and examines patients' perceptions of this information.

MATERIALS AND METHODS: To assess reliability, n = 28 individuals were asked to generate information from GPT-3.5 and Generative Pretrained Transformer 4 (GPT-4) about side effects related to orthodontic treatment using both self-formulated and standardized prompts. Three experts evaluated the content generated based on these prompts regarding its validity. We asked a cohort of 46 orthodontic patients about their perceptions after reading an AI-generated information text about orthodontic side effects and compared it with the standard text from the postgraduate orthodontic program at Aarhus University.

RESULTS: Although the GPT-generated answers mentioned several relevant side effects, the replies were diverse. The experts rated the AI-generated content generally as "neither deficient nor satisfactory," with GPT-4 achieving higher scores than GPT-3.5. The patients perceived the GPT-generated information as more useful and more comprehensive and experienced less nervousness when reading the GPT-generated information. Nearly 80% of patients preferred the AI-generated information over the standard text.

CONCLUSIONS: Although patients generally prefer AI-generated information regarding the side effects of orthodontic treatment, the tested prompts fall short of providing thoroughly satisfactory and high-quality education to patients.

Kennedy class III and IV dental arches

Mon, 01 Jan 2024 21:06:39 +0100

This study aims to evaluate the trueness of Kennedy Class III and IV dental arches digitized by different methods and three-dimensionally (3D) printed using stereolithography technology in an in vitro setup. Reference casts (maxillary Kennedy class III and IV) were produced by computer assisted design and manufacture, and linearly measured at occlusocervical, interarch, and edentulous space dimensions. Intraoral scanner (IOS), extraoral scanner (EOS) and cone beam computed tomography (CBCT) digitized the reference casts. Each digital file was 3D-printed using stereolithography technology, totalizing sixty experimental casts (n=10 per group). The same measurements taken from the reference casts were performed on experimental casts. Two-way ANOVA and Bonferroni post-test were used for trueness (distortion between the experimental and reference casts). Distortion was significantly greater for class IV when compared with class III and increased after the 3D-printing step. Among digitizing methods, IOS and EOS had a similar performance and casts from CBCT showed higher distortion, reaching-1.0 and-1.4 mm in the edentulous spaces of digital and 3D-printed cast, respectively. It was possible to conclude that the trueness of Kennedy class III and IV arches were different according to digitizing processes with higher distortion at the edentulous spaces when the cast was digitized by CBCT and converted to a 3D model, compared to IOS and EOS; and in the Kennedy class IV dental arch condition.

Surgery First and Aligners

Sefidroodi, M., Shino, I. L., Vassis, S., et al. — Fri, 01 Nov 2024 21:06:39 +0100

Continuous advancements in technology have made it possible to integrate clear aligner therapy (CAT) with orthognathic surgery. This case report presents a novel, individually-planned workflow, combining CAT with a surgery-first orthognathic approach (SFOA) in collaborating with engineers for an in-house production of surgical guides and customized titanium plates. The patient was evaluated subjectively, using the Oral Health-Related Quality of Life-14 (OHIP-14) questionnaire and Orthognathic Quality of Life questionnaire (OQLQ), and objectively with the Peer Assessment Rating (PAR) index. The patient displayed the planned occlusal relationship with no report of discomfort in the temporomandibular joint (TMJ) or post-surgical complications. The surgical and occlusal outcomes have remained consistent and stable after debonding. A decreased score was reported in both questionnaires and the PAR after treatment, thereby indicating improvements in both subjective and objective evaluations. This case report demonstrates that with proper individual planning, satisfactory subjective and objective outcomes can be achieved when combining SFOA with CAT.

Prevalence of painful temporomandibular disorders in individuals with post‑traumatic headache attributed to mild traumatic brain injury

Kothari, M., Odgaard, L., Nielsen, J. F., Kothari, S. F. — Mon, 02 Dec 2024 21:06:39 +0100

OBJECTIVES: Studies assessing the presence of painful temporomandibular disorders (TMD) in post-traumatic headache (PTH) attributed to mild traumatic brain injury are lacking. We aimed to (1) measure the prevalence of painful TMD and assess its association with demographic and trauma-related factors in patients with PTH and (2) compare the headache characteristics and post-concussion burden between the PTH patients with and without painful TMD. METHODS: This study embedded in a population-based epidemiologic cohort study (N = 2,832) assessed mild traumatic brain injury patients (18-60 years) 2-4 months after their trauma. PTH patients (n = 382) were identified and invited to fill out questionnaires assessing post-concussion symptoms and burden, headache characteristics, presence of painful TMD and demographics. RESULTS: The prevalence of painful TMD was 22.5%. Living with a partner/spouse (OR = 0.31, 95% CI: 0.13-0.75, P = 0.010) and having a secondary education (OR = 0.28, 95% CI: 0.08-0.99, P = 0.048) was significantly associated with decreased risk of having painful TMD. PTH patients with painful TMD reported significantly higher headache intensity (P < 0.042), increased symptom burden (P = 0.007), reduced workability after trauma (P = 0.019) and were frequently on full-time sick leave compared to those without painful TMD. CONCLUSIONS: PTH patients had a high prevalence of painful TMD. Living with a partner/spouse and having a secondary education decreased the risk of having painful TMD. Patients with painful TMD were significantly heavily burdened compared to those without painful TMD. CLINICAL RELEVANCE: Presence of painful TMD in PTH patients may compromise the rehabilitation plan and complicate the management of these patients.

Risk of pulp necrosis and related complications in the permanent anterior teeth with lateral luxation

Tewari, N., Lauridsen, E., Atif, M., et al. — Tue, 01 Oct 2024 21:06:39 +0200

This systematic review aimed to evaluate the evidence related to the occurrence of pulp necrosis and related complications in permanent anterior teeth with lateral luxation. It was envisaged to address the ambiguity related to the recommendation for pulp extirpation in teeth with mature root apex. An a priori protocol was formulated as per the best practices of evidence-based medicine and registered in PROSPERO. A comprehensive search was performed electronically in PubMed, LILACS, Web of Science, EMBASE, Scopus, and Cochrane on July 10,2023 without any restriction of language or year of publication. The screening of titles and abstracts and later the full-text articles were performed. Later, the data extraction was performed by using a self-designed sheet, risk of bias (ROB) assessment was done, meta-analysis was performed, and the GRADE approach was used to assess the quality of evidence. The qualitative synthesis was performed on 13 studies done from 1985 to 2020 in hospital settings. There was variability in the minimum and total observation periods, sample sizes, and characteristics of the sample population. The overall pooled prevalence of pulp necrosis was found to be 57% (95% CI: 42, 72%). It was 12% (95% CI: 8%, 18%, I² = 0%) in immature teeth, and 58% (95% CI: 42, 73%, I² = 86%) in mature teeth. The pooled prevalence of EIRR was found to be 11% (95% CI: 4, 27%, I² = 95%) with greater risk in teeth with mature root apex (RR: 1.26, 95% CI: 1.12, 1.42, I² = 0%). The ROB was moderate or high in nine studies and the GRADE of evidence was very low in 14 of 15 outcomes. There are greater chances of pulp necrosis in teeth with lateral luxation, especially with mature apex. However, it can still be less than 60% in most cases with the prevalence of EIRR less than 20%. Hence, an absolute recommendation for endodontic intervention in mature teeth with lateral luxation must be interpreted with slight caution.

Impact of obesity on return to work after total knee arthroplasty

Pajaniaye, J., Alsing, P., Stisen, M. G., et al. — Wed, 13 Nov 2024 21:06:39 +0100

Background Total knee arthroplasty (TKA) is an effective and safe treatment of pain and functional impairment in late-stage knee osteoarthritis (OA). In Denmark, 20% of TKAs are performed in patients <60 years of age who can return to work (RTW) after TKA. However, there is limited knowledge about the rate of RTW in this population. Obesity, a major risk factor for TKA complications in terms of incidence and severity, may affect RTW after TKA.
Aim To investigate the association between body mass index (BMI) and rates of RTW in working-age patients with knee OA undergoing TKA. Furthermore, to explore whether the association varies by sex, age, socioeconomic position (SEP), and history of comorbidities.
Materials and Methods We combined data from the Danish Knee Arthroplasty Registry and the Danish Registry for Evaluation of Marginalization, for labor market status. BMI was grouped as normal (<25), pre-obesity (25-29.9), obesity class 1 (30-34.9), 2 (35-39.9), or 3 (≥40). RTW was defined as full- or part-time RTW within 2 years of follow-up. We estimated cumulative incidence proportions (CIP) of RTW (overall and by BMI-group), considering death and early retirement as competing events. Cox proportional hazards models were used to calculate Hazard Ratios (HRs) adjusting for selected confounders.
Results We included 6,162 patients (41% men), median age 55 years (IQR 6.3) and mean BMI 30.8 (95% CI (CI) 30.7;31). The median time to RTW was 69 days (CI 67.6;70). The CIP of RTW at 1 month was 31% (CI: 30;32), at 3 months was 63% (CI 62;65), at 1 year was 92% (CI 92;93), and at 2 years was 96% (CI 95;96). CIPs for RTW in BMI-groups were similar to the overall CIPs, and HRs in BMI-groups were equal to 1. Stratification by age, SEP and comorbidity did not change HRs. Stratification by sex showed no association between BMI and RTW for women, while men in higher BMI-groups had a tendency to lower rate of RTW (HR for obesity class 2 was 0.9 (CI 0.7;1), HR for obesity class 3 was 0.8 (CI 0.7;1) compared to normal BMI).
Interpretation/Conclusion: 31% of TKA patients RTW within 30 days and over 90% RTW within one year. Obesity was not found to affect RTW, but men in obesity class 2 and 3 may need tailored post-TKA rehabilitation to facilitate RTW.

Pano-GAN

Mon, 01 Jan 2024 21:06:39 +0100

Accuracy of occlusal splints printed in different orientations by liquid crystal display technology

Wed, 01 Jan 2025 21:06:39 +0100

Objectives: To evaluate the accuracy of occlusal splints printed in different orientations by liquid crystal display technology. Methods: An occlusal splint was digitally designed, and additively manufactured using an LCD printer (Phrozen Sonic 4k, Phrozen) at three orientations relative to the printer building plate: 0, 45, and 70 degrees (n=10). The 3D-printed occlusal splints were digitised using a desktop scanner, resulting in experimental meshes. The meshes were analysed in a metrology software program, comparing the experimental ones with the initially designed occlusal splint (trueness) and each other within the same group (precision). The discrepancies were shown in a colour map and the root mean square indicated the magnitude of the total discrepancy between the meshes. Kruskal-Wallis test was used (α=0.05) followed by post-hoc Dunn's test. Results: There was no statistical difference in trueness among the groups (P=0.086); however, splints printed at 70 degrees showed better precision compared to those printed at 0 (P<0.001) and 45 degrees (P<0.001). The splints printed at 0 and 45 degrees exhibited a similar discrepancy pattern, with highest values concentrated in the posterior segment—positive on the buccal surface and negative on the lingual surface of molars. In contrast, splints printed at 70 degrees had highest discrepancy values in both anterior and posterior segments, with an inverted pattern on molars. Conclusion: : The accuracy of occlusal splints was affected by the different orientation in terms of precision, with 70 degrees resulted in highest precision compared to 0 and 45 degrees. No difference was found in terms of trueness. Higher discrepancies were found located in molars and incisal edge of anterior teeth. Clinical significance: 3D-printing using LCD technology stands out for its affordability and good resolution, however the optimal printing angle remains unclear. Vertical positioning allows more objects to fit on the printer building plate, while horizontal positioning reduces print time. According to literature, for DLP printers, a 0-degree angle provides good accuracy for occlusal splints, whereas a 90-degree angle results in lower accuracy. This study found that for LCD printers, 0, 45, and 70 degrees had similar trueness, with 70 degrees offering the highest precision. Thus, vertical positioning at 70 degrees can be a safe choice for the accuracy of occlusal splints printed on LCD technology.

Pintin hanaoluesta kolmannes pois

Raittio, E. — Fri, 15 Nov 2024 21:06:39 +0100

A novel chitosan-peptide system for cartilage tissue engineering with adipose-derived stromal cells

Tymińska, A., Karska, N., Skoniecka, A., et al. — Sun, 01 Dec 2024 21:06:39 +0100

The natural healing process of cartilage injuries often fails to fully restore the tissue's biological and mechanical functions. Cartilage grafts are costly and require surgical intervention, often associated with complications such as intraoperative infection and rejection by the recipient due to ischemia. Novel tissue engineering technologies aim to ideally fill the cartilage defect to prevent disease progression or regenerate damaged tissue. Despite many studies on designing biocompatible composites to stimulate chondrogenesis, only few focus on peptides and carriers that promote stem cell proliferation or differentiation to promote healing. Our research aimed to design a carbohydrate chitosan-based biomaterial to stimulate stem cells into the chondrogenesis pathway. Our strategy was to combine chitosan with a novel peptide (UG28) that sequence was based on the copin protein. The construct stimulated human adipose-derived stem cells (AD-SCs) cells to undergo chondrogenic differentiation. Chitosan 75/500 allows AD-SCs to grow and has no harmful effects on the cells. The combination of UG28 peptide with the chitosan composite offers promising properties for cell differentiation, indicating its potential for clinical applications in cartilage regeneration.

COVID-19-related research data availability and quality according to the FAIR principles

Sofi-Mahmudi, A., Raittio, E., Khazaei, Y., et al. — Fri, 01 Nov 2024 21:06:39 +0100

BACKGROUND: According to the FAIR principles (Findable, Accessible, Interoperable, and Reusable), scientific research data should be findable, accessible, interoperable, and reusable. The COVID-19 pandemic has led to massive research activities and an unprecedented number of topical publications in a short time. However, no evaluation has assessed whether this COVID-19-related research data has complied with FAIR principles (or FAIRness).

OBJECTIVE: Our objective was to investigate the availability of open data in COVID-19-related research and to assess compliance with FAIRness.

METHODS: We conducted a comprehensive search and retrieved all open-access articles related to COVID-19 from journals indexed in PubMed, available in the Europe PubMed Central database, published from January 2020 through June 2023, using the metareadr package. Using rtransparent, a validated automated tool, we identified articles with links to their raw data hosted in a public repository. We then screened the link and included those repositories that included data specifically for their pertaining paper. Subsequently, we automatically assessed the adherence of the repositories to the FAIR principles using FAIRsFAIR Research Data Object Assessment Service (F-UJI) and rfuji package. The FAIR scores ranged from 1-22 and had four components. We reported descriptive analysis for each article type, journal category, and repository. We used linear regression models to find the most influential factors on the FAIRness of data.

RESULTS: 5,700 URLs were included in the final analysis, sharing their data in a general-purpose repository. The mean (standard deviation, SD) level of compliance with FAIR metrics was 9.4 (4.88). The percentages of moderate or advanced compliance were as follows: Findability: 100.0%, Accessibility: 21.5%, Interoperability: 46.7%, and Reusability: 61.3%. The overall and component-wise monthly trends were consistent over the follow-up. Reviews (9.80, SD = 5.06, n = 160), articles in dental journals (13.67, SD = 3.51, n = 3) and Harvard Dataverse (15.79, SD = 3.65, n = 244) had the highest mean FAIRness scores, whereas letters (7.83, SD = 4.30, n = 55), articles in neuroscience journals (8.16, SD = 3.73, n = 63), and those deposited in GitHub (4.50, SD = 0.13, n = 2,152) showed the lowest scores. Regression models showed that the repository was the most influential factor on FAIRness scores (R2 = 0.809).

CONCLUSION: This paper underscored the potential for improvement across all facets of FAIR principles, specifically emphasizing Interoperability and Reusability in the data shared within general repositories during the COVID-19 pandemic.

Performance and safety evaluation of a cold ablation robot-guided laser osteotome (CARLO) in 28 midface osteotomies

Köhnke, R., Chin, S. J., Assaf, A. T., et al. — Sun, 01 Dec 2024 21:06:39 +0100

The CARLO (cold ablation robot-guided laser osteotome) is a compact device with integrated multiple sensory, steering and safety checking elements. A multi-center study was performed to evaluate the CARLO device for the linear part of midface osteotomy in 28 patients. Feasibility, success rate, safety, performance and experience of the surgeons were assessed and evaluated. All 28 procedures were completed with CARLO without falling back to the conventional methods, giving a technical success rate of 100%. For 27 (96%) cases, procedural success was achieved with cutting lines deviation less than 2 mm. For 25 procedures, the CARLO-cutting was conducted smoothly. In the other 3 cases, some minor difficulties related to the reference markers were reported. For 18 procedures, no change for the cutting path was necessary. For the other 10 cases, cut path was adapted. Intraoperative re-planning was possible, easy and quick without significant delay of the procedures. No CARLO-related adverse events were recorded. Especially, there was no unexpected and unusual bleeding during the CARLO-conducted osteotomy. The time needed for the registration ranged from 1 to 12 min (median = 4). The CARLO-cutting lasted for 5 to 21 min (median = 7). The present study demonstrated feasibility, simplicity, safety, reliability and accuracy of CARLO for the linear part of midface osteotomy.

Røntgen i forbindelse med implantatbehandling

Schropp, L., Andreasen, K. — Thu, 01 Aug 2024 21:06:39 +0200

Hypohidrotic ectodermal dysplasia caused by an intragenic duplication in EDAR

Graversen, L., Sommerlund, M., Kruse, C., et al. — Sun, 01 Dec 2024 21:06:39 +0100

Hypohidrotic Ectodermal Dysplasia is a syndrome with hypotrichosis, hypohidrosis, and hypodontia as the main symptoms. The prevalence is estimated to one in 5000–10,000 persons. In 10–15% the disease is caused by pathogenic variants in EDAR, and most of the known causal variants to date are missense or nonsense variants. We present a patient with classic Hypohidrotic Ectodermal Dysplasia and mammary gland aplasia with a duplication within EDAR as the likely cause. The duplication is de novo in the patient, and genome sequencing of DNA extracted from blood has revealed that the duplication is in tandem conformation, most likely entailing an altered EDAR protein with a dominant negative effect. This is to our knowledge the first report of an intragenic duplication in EDAR as causal for Hypohidrotic Ectodermal Dysplasia.

Comparison of tendon attachment to 3D printed Ti6Al4V implant versus Trevira® implant

Freund, S. S., Borgognoni, A. B., Bendtsen, M. M., et al. — Sun, 01 Dec 2024 21:06:39 +0100

Background: Soft-tissue attachment is crucial for the success of megaprosthesis surgery and improvement in current treatment is needed. The aim of this study was to compare the biomechanical and histomorphometric properties of soft-tissue attachment between 3D printed Ti6Al4V implants featuring a 630 μm microporous structure and commercially available Trevira® implants with a 200 μm porous structure in a non-loadbearing ovine model. Methods: Ten skeletally mature ewes underwent surgical implantation with both implants. After 4-weeks, mechanical pull-out testing assessed the attachment strength, while histomorphometric analysis evaluated fibroblast cell profile density, multinucleated giant cell profile density, microvessel length and volume density. Results: 3D printed Ti6Al4V implants demonstrated a 129% greater attachment strength compared to Trevira® implants (p = 0.003). In the Trevira® group, a 35% increase in fibroblast profile density (p < 0.001) and a 98% increase in multinucleated giant cell profile density (p < 0.001) were observed, with no significant difference in microvessel length density between the groups. However, the Ti6Al4V group exhibited a 50% higher microvessel volume density (p < 0.001) compared to the Trevira® group. Conclusion: 3D printed Ti6Al4V implants with a 630 μm microporous structure demonstrated superior attachment strength, enhanced neovascularization, and reduced foreign body reaction compared to the Trevira® implants. These findings suggest that 3D printed Ti6Al4V implants may enhance soft-tissue attachment in megaprosthesis surgeries.

A randomized controlled educational study to evaluate an e-learning module to teach the physical examination of the temporomandibular joint in juvenile idiopathic arthritis

Pan, N., Sadun, R. E., Lerman, M. A., et al. — Sun, 01 Dec 2024 21:06:39 +0100

Background: The aim of the study was to evaluate the effectiveness of a novel e-learning module in teaching the physical exam of the temporomandibular joint (TMJ) in Juvenile idiopathic arthritis (JIA.). Methods: An e-learning module was developed to convey the TMJ physical examination maneuvers that are considered to be best practice in JIA. Pediatric rheumatology fellows were randomized to two groups. One group received an article describing the physical examination skills while the second group received both the article and module. All participants completed a written pre-test, an in-person objective structured clinical examination (OSCE), a written post-test, and a follow-up survey. Results: Twenty-two pediatric rheumatology fellows enrolled, with 11 per group. Written test: The two groups improved equally, although there was a trend toward improved defining of maximal incisal opening (MIO) in the module group. OSCE: The mean OSCE score was 11.1 (SD 3.3) in the article group and 13.5 (SD 1.9) in the module group (p = 0.06); significant differences were seen in measuring MIO (p = 0.01), calculating maximal unassisted mouth opening (MUMO; p = 0.01), and assessment of facial symmetry (p = 0.03), all favoring the module. Enjoyment scores in the module group were higher than in the article group (mean 7.7/10 vs. 5.9/10, p = 0.02). The two groups self-reported performing TMJ examinations at comparable rates three months following the intervention. Conclusions: The study demonstrated that a formalized educational program improved knowledge of the physical exam of the TMJ in JIA. Learners viewing the module were more adept at obtaining quantitative TMJ measurements.

Structural MRI findings in the brain related to pain distribution in chronic overlapping pain conditions

Fri, 01 Nov 2024 21:06:39 +0100

Background: Few neuroimaging studies have investigated structural brain differences associated with variations in pain distribution. Objective: To explore structural differences of the brain in fibromyalgia (FM), temporomandibular disorder pain (TMD) and healthy pain-free controls (CON) using structural and diffusion MRI. Methods: A case–control exploratory study with three study groups with different pain distribution were recruited: FM (n = 16; mean age [standard deviation]: 44 [14] years), TMD (n = 17, 39 [14] years) and CON (n = 10, 37 [14] years). Participants were recruited at the University Dental Clinic in Malmö, Sweden. T1-weighted and diffusion MRIs were acquired, clinical and psychosocial measures were obtained. Main outcome measures were subcortical volume, cortical thickness, white matter microstructure and whole brain grey matter intensity. Results: Patients with FM had smaller volume in the right thalamus than patients with TMD (p =.020) and CON (p =.030). The right thalamus volume was negatively correlated to pain intensity (r = −0.37, p =.022) and pain-related disability (r = −0.45, p =.004). The FM group had lower cortical thickness in the right anterior prefrontal cortex than CON (p =.005). Cortical thickness in this area was negatively correlated to pain intensity (r [37] = − 0.48, p =.002). Conclusions: This study suggests that thalamus grey matter alterations are associated with FM and TMD, and that anterior prefrontal cortex grey matter alterations are associated with FM but not TMD. Studies on chronic overlapping pain conditions are needed in relation to possible nociplastic pain mechanisms in the brain and central nervous system.

Large-scale screening identifies enzyme combinations that remove in situ grown oral biofilm

Nielsen, S. M., Johnsen, K. K., Hansen, L. B. S., et al. — Sun, 01 Dec 2024 21:06:39 +0100

Bacteria in the oral cavity are responsible for the development of dental diseases such as caries and periodontitis, but it is becoming increasingly clear that the oral microbiome also benefits human health. Many oral care products on the market are antimicrobial, killing a large part of the oral microbiome but without removing the disease-causing biofilm. Instead, non-biocidal matrix-degrading enzymes may be used to selectively remove biofilm without harming the overall microbiome. The challenge of using enzymes to degrade biofilms is to match the narrow specificity of enzymes with the large structural diversity of extracellular polymeric substances that hold the biofilm together. In this study, we therefore perform a large-scale screening of single and multi-enzyme formulations to identify combinations of enzymes that most effectively remove dental biofilm. We tested >400 different treatment modalities using 44 different enzymes in combinations with up to six enzymes in each formulation, on in vitro biofilms inoculated with human saliva. Mutanase was the only enzyme capable of removing biofilm on its own. Multi-enzyme formulations removed up to 69 % of the biofilm volume, and the most effective formulations all contained mutanase. We shortlisted 10 enzyme formulations to investigate their efficacy against biofilms formed on glass slabs on dental splints worn by 9 different test subjects. Three of the ten formulations removed more than 50 % of the biofilm volume. If optimal enzyme concentration and exposure time can be reached in vivo, these enzyme combinations have potential to be used in novel non-biocidal oral care products for dental biofilm control.

Radiographic graft changes following maxillary sinus floor augmentation with autogenous bone compared with composite grafts

Fri, 01 Nov 2024 21:06:39 +0100

This study evaluated radiographic graft changes following maxillary sinus floor augmentation with (A) autogenous bone, (B) 1:1 autogenous bone and deproteinized porcine bone mineral, or (C) 1:1 autogenous bone and biphasic bone graft material. Sixty patients were randomly allocated to groups A, B, and C (20 in each). CBCT scans were obtained at enrolment, after surgery (T1), after prosthetic rehabilitation (T2), and 1 year after implant loading (T3). Significant decreases in graft volume (3D) and graft height (2D) from T1 to T3 were observed in all groups (P < 0.05). However, at T2 and T3, graft volume was significantly higher in group B than in groups A and C (P < 0.05), and graft height was significantly higher in group B than in group A (P < 0.05). Bone density increased significantly from T1 to T2 in all groups (P < 0.001). However, bone density was significantly higher in group B than in groups A and C, at T2 and T3 (P < 0.05). No significant correlation between graft volume or height and implant protrusion length or residual bone height was found. In conclusion, 1:1 autogenous bone and porcine bone resulted in significantly higher graft volume, height, and bone density when compared with autogenous bone or a 1:1 ratio of autogenous bone and biphasic bone. However the higher graft volume, height, and bone density did not appear to lead to improved outcomes at 1 year of functional loading when compared to the other groups.

Treatment plan for maxillary third molars based on radiological findings varies among oral surgeons

Hermann, L., Nørholt, S. E., Wenzel, A., Berkhout, E., Matzen, L. H. — Fri, 01 Nov 2024 21:06:39 +0100

Objectives: To evaluate variation in treatment plans and pathological findings related to maxillary second and third molars based on panoramic (PAN) images and cone beam CT (CBCT) among Danish and Dutch oral and maxillofacial surgeons. Study Design: This web-based “paper” clinic contained 10 cases of impacted maxillary third molars comprising clinical information, PAN, and CBCT. Treatment plan and pathological findings were established based on clinical information and PAN, thereafter, based on CBCT by 28 surgeons. Options for treatment plan for third molars were no treatment, or tooth removal. Options for treatment plan for second molars were no treatment, tooth removal, or endodontic and/or filling therapy. The surgeons assessed external root resorption, marginal bone loss, and follicular space. Results: A change in treatment plan between PAN and CBCT was registered between 0% and 43% of the surgeons among the cases. The surgeons did not agree completely on the treatment plan in any of the cases. Variation was present among the surgeons evaluating pathological findings. In several cases, severity of root resorption was rated worse in CBCT than in PAN. Conclusions: Variation in treatment plan and pathological findings was observed among surgeons. No correlation between change in pathological findings and change in treatment plan was found.

Lapset ja nuoret juovat yhä enemmän sokerilla makeutettuja juomia

Raittio, E. — Mon, 01 Jan 2024 21:06:39 +0100

Britanniassa sokerivero vähensi hampaan poistoja sairaaloissa

Raittio, E. — Fri, 26 Jan 2024 21:06:39 +0100

Vapetuksen rooli tupakasta vieroituksessa askarruttaa

Raittio, E. — Fri, 22 Mar 2024 21:06:39 +0100

Seulontaan tarvitaan tietoon perustuva suostumus

Raittio, E. — Fri, 17 May 2024 21:06:39 +0200

Comparison of deep learning models to detect crossbites on 2D intraoral photographs

Noeldeke, B., Vassis, S., Sefidroodi, M., Pauwels, R., Stoustrup, P. — Sun, 01 Sep 2024 21:06:39 +0200

Background: To support dentists with limited experience, this study trained and compared six convolutional neural networks to detect crossbites and classify non-crossbite, frontal, and lateral crossbites using 2D intraoral photographs. Methods: Based on 676 photographs from 311 orthodontic patients, six convolutional neural network models were trained and compared to classify (1) non-crossbite vs. crossbite and (2) non-crossbite vs. lateral crossbite vs. frontal crossbite. The trained models comprised DenseNet, EfficientNet, MobileNet, ResNet18, ResNet50, and Xception. Findings: Among the models, Xception showed the highest accuracy (98.57%) in the test dataset for classifying non-crossbite vs. crossbite images. When additionally distinguishing between lateral and frontal crossbites, average accuracy decreased with the DenseNet architecture achieving the highest accuracy among the models with 91.43% in the test dataset. Conclusions: Convolutional neural networks show high potential in processing clinical photographs and detecting crossbites. This study provides initial insights into how deep learning models can be used for orthodontic diagnosis of malocclusions based on intraoral 2D photographs.

Implementation of In-house Computer-aided Design and Manufacturing for Accelerated Free Fibula Flap Reconstruction of Mandibular Defects in Cancer Patients

Lindhardt, J. L., Kiil, B. J., Jakobsen, A. M., Buhl, J., Krag, A. E. — Tue, 27 Aug 2024 21:06:39 +0200

Background: Computer-aided design and manufacturing (CAD/CAM) is widely adopted for optimizing microsurgical reconstruction of mandibular defects. However, commercial solutions are hampered by costs and lengthy lead times, with the latter being problematic in cancer surgery. This study aimed to investigate the efficiency of an in-house CAD/CAM service for expeditious planning and execution of free fibula mandibular reconstruction in head and neck cancer patients. Methods: This retrospective cohort study compared cancer patients undergoing segmental mandibulectomy and immediate free fibula flap reconstruction treated before and after implementation of in-house CAD/CAM. The primary endpoint was treatment delay from preoperative consultation to surgery. Cases in the two groups were matched on the number of fibula segments required for mandibular reconstruction. The control group underwent segmental mandibulectomy and fibula flap reconstruction by "freehand."The CAD/CAM group underwent preoperative virtual surgical planning and CAD/CAM of intraoperative cutting guides for the mandibulectomy and fibula osteotomies. Outcomes were compared with the unpaired t test or Wilcoxon rank-sum test. Results: Sixteen patients were included in both groups. Treatment delay did not increase after implementation of in-house CAD/CAM with a median 6 (range 6-20) days wait in the CAD/CAM group and 8 (6-20) days wait in the control group (P=0.48). Utilization of CAD/CAM significantly reduced fibula flap ischemia time with a mean of 18.4 [95% confidence interval 2.8; 33.9] minutes (P=0.022). Conclusions: In-house CAD/CAM was implemented for free fibula flap mandibular reconstruction in head and neck cancer patients without causing treatment delay. Furthermore, CAD/CAM reduced fibula flap ischemia time.

Assessment of cone-beam CT technical image quality indicators and radiation dose for optimal STL model used in visual surgical planning

Koivisto, J., Wolff, J., Pauwels, R., et al. — Sun, 01 Sep 2024 21:06:39 +0200

Objectives: The aim of this study was to identify cone-beam computed tomography (CBCT) protocols that offer an optimal balance between effective dose (ED) and 3D model for orthognathic virtual surgery planning, using CT as a reference, and to assess whether such protocols can be defined based on technical image quality metrics. Methods: Eleven CBCT (VISO G7, Planmeca Oy, Helsinki, Finland) scan protocols were selected out of 32 candidate protocols, based on ED and technical image quality measurements. Next, an anthropomorphic RANDO SK150 phantom was scanned using these 11 CBCT protocols and 2 CT scanners for bone quantity assessments. The resulting DICOM (Digital Imaging and Communications in Medicine) files were converted into Standard Tessellation Language (STL) models that were used for bone volume and area measurements in the predefined orbital region to assess the validity of each CBCT protocol for virtual surgical planning. Results: The highest CBCT bone volume and area of the STL models were obtained using normal dose protocol (F2) and ultra-low dose protocol (J13), which resulted in 48% and 96% of the mean STL bone volume and 48% and 95% of the bone area measured on CT scanners, respectively. Conclusions: The normal dose CBCT protocol “F2” offered optimal bone area and volume balance for STL. The optimal CBCT protocol can be defined using contrast-to-noise ratio and modulation transfer function values that were similar to those of the reference CT scanners’. CBCT scanners with selected protocols can offer a viable alternative to CT scanners for acquiring STL models for virtual surgical planning at a lower effective dose.

Phenotypes, Genetics, and Estimated Prevalence of Focal Dermal Hypoplasia (Goltz Syndrome)

Herlin, L. K., Herlin, M. K., Vinter, H., et al. — Fri, 01 Nov 2024 21:06:39 +0100

BACKGROUND: Focal dermal hypoplasia (FDH), also known as Goltz syndrome, is a rare ectodermal dysplasia that primarily affects the skin, skeleton, and eyes. It is an X-linked dominant disorder, predominantly seen in females, caused by pathogenic variants in PORCN.

METHODS: We characterized a case series of four genetically confirmed FDH patients (three females, one male) at Aarhus University Hospital, Denmark. We estimated the FDH prevalence from our local cohort and nationwide registry data.

RESULTS: Three patients had characteristic dermatological findings suspicious for FDH and confirmed by targeted PORCN analysis. One patient had an atypical presentation with several malformations but only subtle skin changes and was diagnosed following trio exome-sequencing analysis. Skin atrophy with fat herniations and telangiectasias were typical cutaneous findings. Limb malformations included oligodactyly (cleft foot), syndactyly, and polydactyly. Eye abnormalities included coloboma and microphthalmos. Facial dysmorphology was defined by asymmetry, thin upper lip, and malformed ears. One patient developed a giant cell bone tumor, which is a rare feature of FDH. Dental findings included enamel hypoplasia with vertical grooving and irregular crowns. Four PORCN variants were identified, including three not previously reported in the literature.We estimated a regional point prevalence in Western Denmark of 1.6 cases per million population (95% confidence intervals (CI): 0.7-3.7 per million) and a nationwide registry-based point prevalence of 1.2 cases per million population (95% CI: 0.6-2.4 per million).

CONCLUSIONS: FDH is an extremely rare and complex multisystem disorder of variable presentation, which requires close multidisciplinary collaboration for diagnosis and patient care.

Objective quantitative digital evaluation of crown preparation using intraoral optical scanner: novel preclinical teaching method

Ranjkesh, B., Bahrami, G. — Sun, 01 Sep 2024 21:06:39 +0200

Background: Adequate preclinical training in dentistry is crucial for students before engaging in patient treatment. Constructive feedback from the instructors plays a pivotal role in guiding the students to master skills, boost confidence, and above all ensure patient safety. This manuscript introduces a new method employing intraoral scanners as digital tools to provide objective and quantitative feedback for crown preparation evaluation in preclinical prosthodontics. Material and Methods: Initial reference scan before preparation on typodont and preparation scan after crown preparation was obtained. Utilizing the patient monitoring feature in Trios 3 scanner (3Shape, Copenhagen, Denmark) superimposition of two scans was performed. Results: The method enabled a comprehensive quantitative preparation assessment compared to the tooth pre-preparation. This includes tooth reduction in any axis, abutment height measurement, evaluation of the status of adjacent teeth after preparation, and proposed capability for estimating the convergence angle. Conclusions: The method enabled a subjective quantitative evaluation of crown preparation in phantom model. This method requires no additional hardware or software beyond the basic functions embedded in the intraoral scanner. Implementation of this function not only facilitates feedback and self-evaluation for students during preclinical teaching but also enhances their proficiency in using intraoral scanners in clinical practice in perspective.

Bond strength of resin-based restorative materials to fast-setting calcium silicate cement using different resin adhesive systems

Ranjkesh, B., Kopperud, H. M., Lovschall, H. — Sun, 01 Dec 2024 21:06:39 +0100

This study assessed the bond strength of resin-based restorative materials to fast-setting calcium silicate cement (Aarhus Uinversity, Denmark) when treated with each of two one-bottle universal adhesive systems. The cement surface (N = 256) was treated with a self-priming adhesive and a self-etch phosphate monomer-containing adhesive with and without etching of the cement surface. Specimens then received either resin composite or compomer restorative materials (n = 32). The bond strength was measured after 1 day and 1500 thermocycles (n = 16). The failure type was visually inspected. The cement-adhesive-restorative material interface was visualized using scanning electron microscopy (SEM). The data were analyzed using multiple linear regression. Restorative material type, resin adhesive system, and thermocycling had a statistically significant effect on the bond strength. Compomer restorative material and self-etch universal adhesive system demonstrated statistically significantly higher bond strength values to fast-setting calcium silicate cement, predominantly exhibiting cement cohesive failure. Etching the cement surface enhanced the bond strength of the self-priming universal adhesive. Thermocycling significantly reduced the bond strength. SEM showed self-etch universal adhesive seemingly diffused over the etched cement surface compared to other groups. Self-etch phosphate monomer-containing universal adhesive and compomer resulted in the highest bond strength to fast-setting calcium silicate cement.

Ability of dairy proteins to reduce capsaicin-induced oral burning pain and possible clinical implications

Gøkhan, M. A. — Tue, 06 Aug 2024 21:06:39 +0200

Dentaldedikeret magnetisk resonans – en metode til at diagnosticere, hvad der før var usynligt

Mon, 01 Apr 2024 21:06:39 +0200

A standard set of outcome measures for the comprehensive assessment of oral health and occlusion in individuals with osteogenesis imperfecta

Blokland, L., Arponen, H., Ahmad, A., et al. — Sun, 01 Dec 2024 21:06:39 +0100

Background: Osteogenesis imperfecta (OI) is a group of inherited connective tissue disorders of varying severity characterized by bone fragility. The primary objective of this international multidisciplinary collaboration initiative was to reach a consensus for a standardized set of clinician and patient-reported outcome measures, as well as associated measuring instruments for dental care of individuals with OI, based on the aspects considered important by both experts and patients. This project is a subsequent to the Key4OI project initiated by the Care4BrittleBones foundation which aims to develop a standard set of outcome measures covering a large domain of factors affecting quality of life for people with OI. An international team of experts comprising orthodontists, pediatric dentists, oral and maxillofacial surgeons, and prosthetic dentists used a modified Delphi consensus process to select clinician-reported outcome measures (CROMs) and patient-reported outcome measures (PROMs) to evaluate oral health in individuals with OI. Important domains were identified through a literature review and by professional expertise (both CROMs and PROMs). In three focus groups of individuals with OI, important and relevant issues regarding dental health were identified. The input from the focus groups was used as the basis for the final set of outcome measures: the selected issues were attributed to relevant CROMs and, when appropriate, matched with validated questionnaires to establish the final PROMs which represented best the specific oral health-related concerns of individuals with OI. Results: Consensus was reached on selected CROMs and PROMs for a standard set of outcome measures and measuring instruments of oral health in individuals with OI. Conclusions: Our project resulted in consensus statements for standardization oral health PROMs and CROMs in individuals with OI. This outcome set can improve the standard of care by incorporating recommendations of professionals involved in dental care of individuals with OI. Further, it can facilitate research and international research co-operation. In addition, the significant contribution of the focus groups highlights the relevance of dental and oral health-related problems of individuals with OI.

Publications - Publications

Forekomst af apikal parodontitis og rodbehandlinger i unge permanente tænder

Hybrid Orthodontics for Aesthetic Deep Bite Correction—Case Series and General Clinical Considerations

Acquired Dentofacial Deformity and Asymmetry

ASU effect on bone repair in defects grafted with bone substitute

Non-radioactive strontium as a supplement to enhance osseointegration

The adjunctive use of systemic antibiotics in the non-surgical and surgical treatment of peri-implantitis

Maxillary rhinosinusitis of odontogenic origin

Avaliação da perda óssea utilizando diferentes parâmetros na análise microtomográfica. Estudo em ratos

Surveying the landscape of diagnostic imaging in dentistry's future

Dentale Magnetresonanztomographie

pH-FISH - coupled microscale analysis of microbial identity and acid–base metabolism in complex biofilm samples

Digital Workflows for Design and Fabrication of the Mandibular Anterior Repositioning Appliance

Guidelines for a surgery-first approach using Dolphin Imaging software and the Invisalign system

Does the use of centring rings change the number of retakes or frequency and size of cone cuts in intraoral images performed by dental students?

Scout images acquired prior to cone beam CT acquisitions

Oral conditions are associated with salt taste disability among American adults

An Explainable and Conformal AI Model to Detect Temporomandibular Joint Involvement in Children Suffering from Juvenile Idiopathic Arthritis

Large-Language Models in Orthodontics

Kennedy class III and IV dental arches

Surgery First and Aligners

Prevalence of painful temporomandibular disorders in individuals with post‑traumatic headache attributed to mild traumatic brain injury

Risk of pulp necrosis and related complications in the permanent anterior teeth with lateral luxation

Impact of obesity on return to work after total knee arthroplasty

Pano-GAN

Accuracy of occlusal splints printed in different orientations by liquid crystal display technology

Pintin hanaoluesta kolmannes pois

A novel chitosan-peptide system for cartilage tissue engineering with adipose-derived stromal cells

COVID-19-related research data availability and quality according to the FAIR principles

Performance and safety evaluation of a cold ablation robot-guided laser osteotome (CARLO) in 28 midface osteotomies

Røntgen i forbindelse med implantatbehandling

Hypohidrotic ectodermal dysplasia caused by an intragenic duplication in EDAR

Comparison of tendon attachment to 3D printed Ti6Al4V implant versus Trevira® implant

A randomized controlled educational study to evaluate an e-learning module to teach the physical examination of the temporomandibular joint in juvenile idiopathic arthritis

Structural MRI findings in the brain related to pain distribution in chronic overlapping pain conditions

Large-scale screening identifies enzyme combinations that remove in situ grown oral biofilm

Radiographic graft changes following maxillary sinus floor augmentation with autogenous bone compared with composite grafts

Treatment plan for maxillary third molars based on radiological findings varies among oral surgeons

Lapset ja nuoret juovat yhä enemmän sokerilla makeutettuja juomia

Britanniassa sokerivero vähensi hampaan poistoja sairaaloissa

Vapetuksen rooli tupakasta ­vieroituksessa askarruttaa

Seulontaan tarvitaan tietoon perustuva suostumus

Comparison of deep learning models to detect crossbites on 2D intraoral photographs

Implementation of In-house Computer-aided Design and Manufacturing for Accelerated Free Fibula Flap Reconstruction of Mandibular Defects in Cancer Patients

Assessment of cone-beam CT technical image quality indicators and radiation dose for optimal STL model used in visual surgical planning

Phenotypes, Genetics, and Estimated Prevalence of Focal Dermal Hypoplasia (Goltz Syndrome)

Objective quantitative digital evaluation of crown preparation using intraoral optical scanner: novel preclinical teaching method

Bond strength of resin-based restorative materials to fast-setting calcium silicate cement using different resin adhesive systems

Ability of dairy proteins to reduce capsaicin-induced oral burning pain and possible clinical implications

Dentaldedikeret magnetisk resonans – en metode til at diagnosticere, hvad der før var usynligt

A standard set of outcome measures for the comprehensive assessment of oral health and occlusion in individuals with osteogenesis imperfecta

Vapetuksen rooli tupakasta vieroituksessa askarruttaa